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MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 [ Homo sapiens (human) ]

Gene ID: 64780, updated on 2-Nov-2024

Summary

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Official Symbol
MICAL1provided by HGNC
Official Full Name
microtubule associated monooxygenase, calponin and LIM domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20619
See related
Ensembl:ENSG00000135596 MIM:607129; AllianceGenome:HGNC:20619
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MICAL; NICAL; MICAL-1
Summary
This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 31.4), lymph node (RPKM 25.8) and 23 other tissues See more
Orthologs
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Genomic context

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See MICAL1 in Genome Data Viewer
Location:
6q21
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (109444062..109465968, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (110622100..110644006, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (109765265..109787171, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17458 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:109703563-109704072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24923 Neighboring gene Sharpr-MPRA regulatory region 15445 Neighboring gene CD164 molecule Neighboring gene peptidylprolyl isomerase like 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:109761883-109762088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:109775979-109776487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:109801913-109802414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17464 Neighboring gene sphingomyelin phosphodiesterase 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:109811810-109812520 Neighboring gene zinc finger and BTB domain containing 24 Neighboring gene ZBTB24 divergent transcript Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109828991-109829516 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109829517-109830042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109834827-109835332 Neighboring gene adenylate kinase 9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110000392-110001073 Neighboring gene MPRA-validated peak6018 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24932 Neighboring gene FIG4 phosphoinositide 5-phosphatase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly. Hung RJ, et al. Cytoskeleton (Hoboken), 2011 Aug. PMID 21800438, Free PMC Article
  2. Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein. Schmidt EF, et al. J Neurosci, 2008 Feb 27. PMID 18305261, Free PMC Article
  3. Structure-function studies of MICAL, the unusual multidomain flavoenzyme involved in actin cytoskeleton dynamics. Vanoni MA. Arch Biochem Biophys, 2017 Oct 15. PMID 28602956
  4. Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy. Dazzo E, et al. Ann Neurol, 2018 Mar. PMID 29394500
  5. Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain. Jin X, et al. Biophys Chem, 2007 Sep. PMID 17662518

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.
    Title: PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.
  2. High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.
    Title: High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.
  3. Mical modulates Tau toxicity via cysteine oxidation in vivo.
    Title: Mical modulates Tau toxicity via cysteine oxidation in vivo.
  4. MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/beta-catenin signaling pathway.
    Title: MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway.
  5. MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.
    Title: MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.
  6. GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.
    Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.
  7. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
    Title: MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
  8. Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.
    Title: Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.
  9. our results suggest that MICAL1 exhibits its effect on proliferation via maintaining cyclin D expression through ROS-sensitive PI3K/Akt/ERK signalling in breast cancer cells
    Title: MICAL1 facilitates breast cancer cell proliferation via ROS-sensitive ERK/cyclin D pathway.
  10. Two autosomal-dominant lateral temporal epilepsy-causing variants were identified in the MICAL1 gene.
    Title: Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ11937, FLJ21739, DKFZp434B1517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables F-actin monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD(P)H oxidase H2O2-forming activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPH oxidase H202-forming activity IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoskeleton organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of regulated secretory pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in sulfur oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in hippocampal mossy fiber expansion IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intermediate filament NAS
Non-traceable Author Statement
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
[F-actin]-monooxygenase MICAL1
Names
NEDD9-interacting protein with calponin homology and LIM domains
[F-actin]-methionine sulfoxide oxidase MICAL1
molecule interacting with CasL protein 1
protein-methionine sulfoxide oxidase MICAL1
NP_001152763.1
NP_001273542.1
NP_073602.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042833.1 RefSeqGene

    Range
    15197..26907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159291.2 → NP_001152763.1  [F-actin]-monooxygenase MICAL1 isoform 2

    See identical proteins and their annotated locations for NP_001152763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it lacks an alternate in-frame exon in the central coding region, compared to variant 3. The encoded isoform (2, also known as MICAL-1b) is shorter at the N-terminus, compared to isoform 3.
    Source sequence(s)
    AB048948, BC009972, BC042144
    Consensus CDS
    CCDS55047.1
    UniProtKB/TrEMBL
    A0A1S5UZH2
    Related
    ENSP00000351385.3, ENST00000358577.7
    Conserved Domains (5) summary
    cd09358
    Location:611 → 664
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    pfam00307
    Location:425 → 521
    CH; Calponin homology (CH) domain
    pfam12130
    Location:841 → 974
    DUF3585; Protein of unknown function (DUF3585)
    pfam13450
    Location:89 → 116
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam16602
    Location:527 → 607
    USP19_linker; Linker region of USP19 deubiquitinase

  2. NM_001286613.2 → NP_001273542.1  [F-actin]-monooxygenase MICAL1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transrcript and encodes the longest isoform (3).
    Source sequence(s)
    AK296284, AL109947, BC042144
    Consensus CDS
    CCDS69170.1
    UniProtKB/TrEMBL
    A0A1S5UZH2
    Related
    ENSP00000486901.1, ENST00000630715.2
    Conserved Domains (5) summary
    cd09358
    Location:716 → 769
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    pfam00307
    Location:530 → 626
    CH; Calponin homology (CH) domain
    pfam12130
    Location:946 → 1079
    DUF3585; Protein of unknown function (DUF3585)
    pfam13450
    Location:108 → 135
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam16602
    Location:632 → 712
    USP19_linker; Linker region of USP19 deubiquitinase

  3. NM_022765.4 → NP_073602.3  [F-actin]-monooxygenase MICAL1 isoform 1

    See identical proteins and their annotated locations for NP_073602.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate 5' exon and thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 3. The encoded isoform (1, also known as MICAL-1a) is shorter at the N-terminus, compared to isoform 3.
    Source sequence(s)
    BC042144
    Consensus CDS
    CCDS5076.1
    UniProtKB/Swiss-Prot
    B7Z3R5, E1P5F0, Q7Z633, Q8IVS9, Q8TDZ2, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7
    UniProtKB/TrEMBL
    A0A1S5UZH2
    Related
    ENSP00000351664.3, ENST00000358807.8
    Conserved Domains (5) summary
    cd09358
    Location:697 → 750
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    pfam00307
    Location:511 → 607
    CH; Calponin homology (CH) domain
    pfam12130
    Location:927 → 1060
    DUF3585; Protein of unknown function (DUF3585)
    pfam13450
    Location:89 → 116
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam16602
    Location:613 → 693
    USP19_linker; Linker region of USP19 deubiquitinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    109444062..109465968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    110622100..110644006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TDZ2.2 GenPept UniProtKB/Swiss-Prot:Q8TDZ2

Gene LinkOut

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