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Krt81 keratin 81 [ Mus musculus (house mouse) ]

Gene ID: 64818, updated on 2-Nov-2024

Summary

Official Symbol
Krt81provided by MGI
Official Full Name
keratin 81provided by MGI
Primary source
MGI:MGI:1928858
See related
Ensembl:ENSMUSG00000067615 AllianceGenome:MGI:1928858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Krt2-19
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in breast cancer; hair disease; and monilethrix. Orthologous to human KRT81 (keratin 81). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

See Krt81 in Genome Data Viewer
Location:
15 F2; 15 56.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101356942..101361646, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101459061..101463765, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 87 Neighboring gene keratin 88 Neighboring gene keratin 86 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316581-101316768 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316810-101316963 Neighboring gene keratin 83

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type II cuticular Hb1
Names
K81
keratin complex 2, basic, gene 19
type II hair keratin Hb1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166157.1NP_001159629.1  keratin, type II cuticular Hb1

    See identical proteins and their annotated locations for NP_001159629.1

    Status: VALIDATED

    Source sequence(s)
    AC103674, AC157583
    Consensus CDS
    CCDS49734.1
    UniProtKB/Swiss-Prot
    E9QLY5, Q9ERE2
    UniProtKB/TrEMBL
    Q61726
    Related
    ENSMUSP00000056525.7, ENSMUST00000061185.8
    Conserved Domains (2) summary
    pfam00038
    Location:105416
    Filament; Intermediate filament protein
    pfam16208
    Location:3102
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101356942..101361646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)