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NABP1 nucleic acid binding protein 1 [ Homo sapiens (human) ]

Gene ID: 64859, updated on 7-Apr-2024

Summary

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Official Symbol
NABP1provided by HGNC
Official Full Name
nucleic acid binding protein 1provided by HGNC
Primary source
HGNC:HGNC:26232
See related
Ensembl:ENSG00000173559 MIM:612103; AllianceGenome:HGNC:26232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSB2; OBFC2A; SOSS-B2; NABP1-OT1
Summary
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Expression
Broad expression in appendix (RPKM 17.5), spleen (RPKM 12.9) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
2q32.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (191678136..191686943)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (192167017..192175824)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (192542862..192551669)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985833 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:192406286-192406448 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:192428730-192429929 Neighboring gene Sharpr-MPRA regulatory region 3391 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5925 Neighboring gene uncharacterized LOC124905959 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:192510916-192511055 Neighboring gene Sharpr-MPRA regulatory region 14503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:192542703-192543205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12197 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:192544033-192545232 Neighboring gene uncharacterized LOC124900605 Neighboring gene uncharacterized LOC124908062

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Novel lncRNA, AK130181, Contributes to HIV-1 Latency by Regulating Viral Promoter-Driven Gene Expression in Primary CD4(+) T Cells. Li H, et al. Mol Ther Nucleic Acids, 2020 Jun 5. PMID 32408053, Free PMC Article
  2. hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage. Boucher D, et al. Sci Rep, 2021 Oct 12. PMID 34642383, Free PMC Article
  3. DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival. Shen Z, et al. Oncotarget, 2016 Nov 29. PMID 27793000, Free PMC Article
  4. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. Li Y, et al. J Biol Chem, 2009 Aug 28. PMID 19605351, Free PMC Article
  5. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Richard DJ, et al. Nature, 2008 May 29. PMID 18449195

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage.
    Title: hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage.
  2. SNPs rs11903757, with closest proximity to NABP1 and SDPR, and rs966423 in DIRC3, were associated with survival in laryngeal squamous cell carcinoma patients.
    Title: DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival.
  3. hSSB1 and hSSB2 form two separate complexes with similar structures, and both complexes participate in DNA damage response.
    Title: HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ13624, FLJ22833, FLJ26671, MGC111163, DKFZp667M1322

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2/M transition checkpoint IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic G2/M transition checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SOSS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SOSS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SOSS complex subunit B2
Names
NABP1 3'UTR overlapping transcript 1
lncRNA AK130181
oligonucleotide/oligosaccharide-binding fold containing 2A
oligonucleotide/oligosaccharide-binding fold-containing protein 2A
sensor of single-strand DNA complex subunit B2
sensor of ssDNA subunit B2
single-stranded DNA-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031716.5 → NP_001026886.1  SOSS complex subunit B2 isoform 1

    See identical proteins and their annotated locations for NP_001026886.1

    Status: VALIDATED

    Source sequence(s)
    AC114778
    Consensus CDS
    CCDS33352.1
    UniProtKB/Swiss-Prot
    Q658Y8, Q96AH0, Q9H5X6
    UniProtKB/TrEMBL
    H7C0W4
    Related
    ENSP00000403683.2, ENST00000425611.9
    Conserved Domains (1) summary
    cd04491
    Location:22 → 99
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

  2. NM_001254736.3 → NP_001241665.1  SOSS complex subunit B2 isoform 2

    See identical proteins and their annotated locations for NP_001241665.1

    Status: VALIDATED

    Source sequence(s)
    AC114778
    Consensus CDS
    CCDS58745.1
    UniProtKB/Swiss-Prot
    Q96AH0
    Related
    ENSP00000387243.1, ENST00000410026.7

RNA

  1. NR_045622.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114778
    Related
    ENST00000307834.9

  2. NR_045623.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114778

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    191678136..191686943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445531.1 → XP_047301487.1  SOSS complex subunit B2 isoform X1

  2. XM_047445532.1 → XP_047301488.1  SOSS complex subunit B2 isoform X1

    Related
    ENSP00000390901.1, ENST00000451500.5

RNA

  1. XR_007080680.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    192167017..192175824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343422.1 → XP_054199397.1  SOSS complex subunit B2 isoform X1

  2. XM_054343423.1 → XP_054199398.1  SOSS complex subunit B2 isoform X1

RNA

  1. XR_008486492.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_131917.1: Suppressed sequence

    Description
    NR_131917.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96AH0.1 GenPept UniProtKB/Swiss-Prot:Q96AH0

Gene LinkOut

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