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Lpin2 lipin 2 [ Mus musculus (house mouse) ]

Gene ID: 64898, updated on 2-Nov-2024

Summary

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Official Symbol
Lpin2provided by MGI
Official Full Name
lipin 2provided by MGI
Primary source
MGI:MGI:1891341
See related
Ensembl:ENSMUSG00000024052 AllianceGenome:MGI:1891341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610511G02Rik
Summary
Enables phosphatidate phosphatase activity and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II and triglyceride biosynthetic process. Located in cytosol and endoplasmic reticulum membrane. Is expressed in central nervous system; gonad; liver; lung; and retina. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis. Orthologous to human LPIN2 (lipin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 8.0), liver E18 (RPKM 7.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lpin2 in Genome Data Viewer
Location:
17 E1.3; 17 41.87 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71490527..71556813)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71183532..71249818)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53974 Neighboring gene myomesin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:71533967-71534150 Neighboring gene STARR-positive B cell enhancer ABC_E4223 Neighboring gene STARR-positive B cell enhancer mm9_chr17:71564522-71564823 Neighboring gene STARR-positive B cell enhancer mm9_chr17:71573946-71574247 Neighboring gene elastin microfibril interfacer 2 Neighboring gene RIKEN cDNA 4930471L23 gene Neighboring gene STARR-seq mESC enhancer starr_43173 Neighboring gene ubiquitin specific peptidase 16 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lipin2 ameliorates diabetic encephalopathy via suppressing JNK/ERK-mediated NLRP3 inflammasome overactivation. Zhang X, et al. Int Immunopharmacol, 2023 May. PMID 37001383
  2. Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance. Ryu D, et al. Diabetes, 2011 Apr. PMID 21357464, Free PMC Article
  3. Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation. Eaton JM, et al. J Biol Chem, 2014 Jun 27. PMID 24811178, Free PMC Article
  4. Lipin-2 degradation elicits a proinflammatory gene signature in macrophages. Watahiki A, et al. Biochem Biophys Res Commun, 2020 Apr 2. PMID 32008742
  5. Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration. Lutkewitte AJ, et al. Food Chem Toxicol, 2018 May. PMID 29534981, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipin2 ameliorates diabetic encephalopathy via suppressing JNK/ERK-mediated NLRP3 inflammasome overactivation.
    Title: Lipin2 ameliorates diabetic encephalopathy via suppressing JNK/ERK-mediated NLRP3 inflammasome overactivation.
  2. Deficiency of Lipin2 Results in Enhanced NF-kappaB Signaling and Osteoclast Formation in RAW-D Murine Macrophages.
    Title: Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages.
  3. Lipin-2 degradation elicits a proinflammatory gene signature in macrophages.
    Title: Lipin-2 degradation elicits a proinflammatory gene signature in macrophages.
  4. These data implicate lipin 2/3 as a control point for enterocyte phospholipid homeostasis and chylomicron biogenesis.
    Title: Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.
  5. Suppression of lipin 1 and lipin2 are the primary mechanism of increased phosphatidic acid levels in the liver during acetaminophen-induced liver injury and recovery.
    Title: Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
  6. Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond but the phosphorylation of lipin 2 is not induced by insulin signaling.
    Title: Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.
  7. in addition to their roles during early adipogenesis, lipin1 and lipin2 also have a role in lipid droplet biogenesis.
    Title: Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.
  8. Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
    Title: Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
  9. role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages
    Title: Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.
  10. Data show that in the high-Chol diet apoE-KO mice, the mRNA and protein expression of lipin-1 and lipin-2 was markedly decreased.
    Title: Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidate phosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidate phosphatase LPIN2
NP_001158357.1
NP_001344720.1
NP_075020.2
XP_006524849.1
XP_006524851.1
XP_030105837.1
XP_030105838.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164885.1 → NP_001158357.1  phosphatidate phosphatase LPIN2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC126942, AC154218, AW489885
    Consensus CDS
    CCDS50177.1
    UniProtKB/TrEMBL
    E9PWN0
    Related
    ENSMUSP00000118610.2, ENSMUST00000126681.8
    Conserved Domains (3) summary
    pfam04571
    Location:39 → 144
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:672 → 897
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:504 → 594
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  2. NM_001357791.1 → NP_001344720.1  phosphatidate phosphatase LPIN2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126942, AC154218, AW489885
    Consensus CDS
    CCDS28956.1
    UniProtKB/Swiss-Prot
    Q8C357, Q8C7I8, Q8CC85, Q8CHR7, Q99PI5
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:634 → 859
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:466 → 556
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  3. NM_022882.4 → NP_075020.2  phosphatidate phosphatase LPIN2 isoform 2

    See identical proteins and their annotated locations for NP_075020.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC126942, AC154218, AW489885
    Consensus CDS
    CCDS28956.1
    UniProtKB/Swiss-Prot
    Q8C357, Q8C7I8, Q8CC85, Q8CHR7, Q99PI5
    Related
    ENSMUSP00000119282.2, ENSMUST00000129635.8
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:634 → 859
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:466 → 556
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    71490527..71556813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249977.1 → XP_030105837.1  phosphatidate phosphatase LPIN2 isoform X3

    Conserved Domains (3) summary
    pfam04571
    Location:1 → 64
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:602 → 827
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:434 → 524
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  2. XM_030249978.2 → XP_030105838.1  phosphatidate phosphatase LPIN2 isoform X4

    Conserved Domains (2) summary
    pfam08235
    Location:373 → 598
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:205 → 295
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  3. XM_006524786.4 → XP_006524849.1  phosphatidate phosphatase LPIN2 isoform X1

    Conserved Domains (3) summary
    pfam04571
    Location:39 → 102
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:640 → 865
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:472 → 562
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  4. XM_006524788.4 → XP_006524851.1  phosphatidate phosphatase LPIN2 isoform X2

    See identical proteins and their annotated locations for XP_006524851.1

    UniProtKB/Swiss-Prot
    Q8C357, Q8C7I8, Q8CC85, Q8CHR7, Q99PI5
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:634 → 859
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:466 → 556
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PI5.2 GenPept UniProtKB/Swiss-Prot:Q99PI5

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