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Lpin3 lipin 3 [ Mus musculus (house mouse) ]

Gene ID: 64899, updated on 2-Nov-2024

Summary

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Official Symbol
Lpin3provided by MGI
Official Full Name
lipin 3provided by MGI
Primary source
MGI:MGI:1891342
See related
Ensembl:ENSMUSG00000027412 AllianceGenome:MGI:1891342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4023; 9130206L11Rik
Summary
Enables phosphatidate phosphatase activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; and triglyceride biosynthetic process. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; skin; and trachea. Orthologous to human LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 11.4), large intestine adult (RPKM 11.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Lpin3 in Genome Data Viewer
Location:
2 H2; 2 80.98 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (160722590..160747920)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (160880670..160906000)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phospholipase C, gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene STARR-positive B cell enhancer ABC_E6012 Neighboring gene predicted gene, 35129 Neighboring gene uncharacterized LOC118568533 Neighboring gene elastin microfibril interfacer 3 Neighboring gene predicted gene, 35181

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3. Boroda S, et al. J Biol Chem, 2017 Dec 15. PMID 28982975, Free PMC Article
  2. Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis. Zhang P, et al. J Clin Invest, 2019 Jan 2. PMID 30507612, Free PMC Article
  3. Lipin-1 and lipin-3 together determine adiposity in vivo. Csaki LS, et al. Mol Metab, 2014 Apr. PMID 24634820, Free PMC Article
  4. Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1. Wang F, et al. Front Med, 2024 Feb. PMID 37776435
  5. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. Donkor J, et al. J Biol Chem, 2007 Feb 9. PMID 17158099

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1.
    Title: Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1.
  2. These data implicate lipin 2/3 as a control point for enterocyte phospholipid homeostasis and chylomicron biogenesis.
    Title: Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.
  3. Data suggest that phosphorylation does not affect catalytic activity of lipin 3 or its ability to associate with phosphatidic acid in vitro; different polybasic domains in lipin 1 and lipin 3 are responsible for phospho-regulation on the former but not the latter enzyme.
    Title: The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3.
  4. Lipin-3 exhibits phosphatidate phosphatase type-1 (PAP1) activity, which has a key role in glycerolipid synthesis.
    Title: Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4023, MGC143991, MGC143992

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
phosphatidate phosphatase LPIN3
NP_001186047.1
NP_075021.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199118.2 → NP_001186047.1  phosphatidate phosphatase LPIN3

    See identical proteins and their annotated locations for NP_001186047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL590389
    Consensus CDS
    CCDS16998.1
    UniProtKB/Swiss-Prot
    Q3TQ75, Q8C7R9, Q99PI4
    UniProtKB/TrEMBL
    A2A4B1, Q149B0
    Related
    ENSMUSP00000043053.7, ENSMUST00000040872.13
    Conserved Domains (4) summary
    COG5083
    Location:1 → 816
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:589 → 814
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:435 → 525
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  2. NM_022883.4 → NP_075021.1  phosphatidate phosphatase LPIN3

    See identical proteins and their annotated locations for NP_075021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL590389
    Consensus CDS
    CCDS16998.1
    UniProtKB/Swiss-Prot
    Q3TQ75, Q8C7R9, Q99PI4
    UniProtKB/TrEMBL
    A2A4B1, Q149B0
    Related
    ENSMUSP00000105082.3, ENSMUST00000109456.9
    Conserved Domains (4) summary
    COG5083
    Location:1 → 816
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:589 → 814
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:435 → 525
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    160722590..160747920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_374500.4 RNA Sequence

  2. XR_374499.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PI4.1 GenPept UniProtKB/Swiss-Prot:Q99PI4

Gene LinkOut

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