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Scel sciellin [ Mus musculus (house mouse) ]

Gene ID: 64929, updated on 2-Nov-2024

Summary

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Official Symbol
Scelprovided by MGI
Official Full Name
sciellinprovided by MGI
Primary source
MGI:MGI:1891228
See related
Ensembl:ENSMUSG00000022123 AllianceGenome:MGI:1891228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9230114I02Rik
Summary
Predicted to enable metal ion binding activity. Involved in embryo development and epidermis development. Located in cytoplasm. Is expressed in several structures, including amnion; brain; genitourinary system; and skin. Orthologous to human SCEL (sciellin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 2.3), limb E14.5 (RPKM 1.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Scel in Genome Data Viewer
Location:
14 E2.3; 14 52.51 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (103750499..103850782)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (103513061..103613346)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700087I21 gene Neighboring gene STARR-seq mESC enhancer starr_37502 Neighboring gene STARR-seq mESC enhancer starr_37503 Neighboring gene STARR-positive B cell enhancer ABC_E10840 Neighboring gene STARR-positive B cell enhancer ABC_E5464 Neighboring gene predicted gene, 34907 Neighboring gene STARR-seq mESC enhancer starr_37505 Neighboring gene STARR-seq mESC enhancer starr_37506 Neighboring gene STARR-seq mESC enhancer starr_37507 Neighboring gene STARR-positive B cell enhancer ABC_E10841 Neighboring gene SLAIN motif family, member 1 Neighboring gene STARR-seq mESC enhancer starr_37509 Neighboring gene SLAIN motif family, member 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_37510 Neighboring gene predicted gene, 35197 Neighboring gene predicted gene, 35116

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. Champliaud MF, et al. Genomics, 2000 Dec 1. PMID 11112355
  2. Targeted deletion of the sciellin gene resulted in normal development and maturation. Baden HP, et al. Genesis, 2005 Aug. PMID 16028229
  3. Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice. Burgess RW, et al. Mol Cell Biol, 2004 Feb. PMID 14729956, Free PMC Article
  4. Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14. Peterson KA, et al. Genomics, 2002 Aug. PMID 12160731
  5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC132819, MGC132820

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epidermis development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epidermis development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sciellin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022886.2 → NP_075024.2  sciellin

    See identical proteins and their annotated locations for NP_075024.2

    Status: VALIDATED

    Source sequence(s)
    AC125201, AF245700, BY775767
    Consensus CDS
    CCDS37002.1
    UniProtKB/Swiss-Prot
    Q9CTT9, Q9EQG3
    UniProtKB/TrEMBL
    Q14DQ7, Q14DU0
    Related
    ENSMUSP00000093233.4, ENSMUST00000095576.5
    Conserved Domains (1) summary
    smart00132
    Location:584 → 642
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    103750499..103850782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519356.4 → XP_006519419.1  sciellin isoform X2

    UniProtKB/TrEMBL
    Q14DQ7
    Conserved Domains (1) summary
    smart00132
    Location:583 → 641
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

  2. XM_006519355.5 → XP_006519418.1  sciellin isoform X1

    See identical proteins and their annotated locations for XP_006519418.1

    UniProtKB/Swiss-Prot
    Q9CTT9, Q9EQG3
    UniProtKB/TrEMBL
    Q14DQ7, Q14DU0
    Conserved Domains (1) summary
    smart00132
    Location:584 → 642
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQG3.2 GenPept UniProtKB/Swiss-Prot:Q9EQG3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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