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Ap3m2 adaptor-related protein complex 3, mu 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 64933, updated on 2-Nov-2024

Summary

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Official Symbol
Ap3m2provided by MGI
Official Full Name
adaptor-related protein complex 3, mu 2 subunitprovided by MGI
Primary source
MGI:MGI:1929214
See related
Ensembl:ENSMUSG00000031539 AllianceGenome:MGI:1929214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AP-3B; 5830445E16Rik
Summary
Involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in central nervous system; ganglia; and sensory organ. Orthologous to human AP3M2 (adaptor related protein complex 3 subunit mu 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 20.8), frontal lobe adult (RPKM 18.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Ap3m2 in Genome Data Viewer
Location:
8 A2; 8 11.42 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23277370..23297308, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22787354..22807292, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene inhibitor of kappaB kinase beta Neighboring gene predicted gene 15346 Neighboring gene STARR-seq mESC enhancer starr_20910 Neighboring gene plasminogen activator, tissue Neighboring gene RIKEN cDNA 1700041G16 gene Neighboring gene STARR-seq mESC enhancer starr_20911 Neighboring gene STARR-positive B cell enhancer ABC_E188 Neighboring gene STARR-positive B cell enhancer ABC_E8844 Neighboring gene STARR-positive B cell enhancer ABC_E2859 Neighboring gene STARR-positive B cell enhancer ABC_E6627 Neighboring gene STARR-positive B cell enhancer ABC_E2259 Neighboring gene STARR-seq mESC enhancer starr_20912 Neighboring gene predicted gene, 46036 Neighboring gene predicted gene, 24735 Neighboring gene K(lysine) acetyltransferase 6A Neighboring gene mitochondrial ribosomal protein L4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a QTL in Mus musculus for alcohol preference, withdrawal, and Ap3m2 expression using integrative functional genomics and precision genetics. Bubier JA, et al. Genetics, 2014 Aug. PMID 24923803, Free PMC Article
  2. Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. Nakatsu F, et al. J Cell Biol, 2004 Oct 25. PMID 15492041, Free PMC Article
  3. The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes. Blumstein J, et al. J Neurosci, 2001 Oct 15. PMID 11588176, Free PMC Article
  4. Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice. Misawa H, et al. Eur J Neurosci, 2008 Jun. PMID 18554297
  5. Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain. Seong E, et al. Mol Biol Cell, 2005 Jan. PMID 15537701, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in anterograde axonal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anterograde synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin-coated vesicle cargo loading, AP-3-mediated NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle coating NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle recycling NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-3 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-3 complex subunit mu-2
Names
HA1 47 kDa subunit homolog 2
P47B
adapter-related protein complex 3 mu-2 subunit
adapter-related protein complex 3 subunit mu-2
adaptor-related protein complex 3 subunit mu-2
clathrin assembly protein assembly protein complex 1 medium chain homolog 2
clathrin assembly protein assembly protein complex 3 mu-2 medium chain
clathrin coat assembly protein AP47 homolog 2
clathrin coat-associated protein AP47 homolog 2
golgi adaptor AP-1 47 kDa protein homolog 2
m3B
mu3B-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122820.1 → NP_001116292.1  AP-3 complex subunit mu-2

    See identical proteins and their annotated locations for NP_001116292.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK081220, BB610934, BY121529
    Consensus CDS
    CCDS22184.1
    UniProtKB/Swiss-Prot
    Q3UYJ3, Q8R2R9, Q923G7
    Related
    ENSMUSP00000128446.2, ENSMUST00000163739.3
    Conserved Domains (2) summary
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
    cl10970
    Location:165 → 418
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  2. NM_029505.3 → NP_083781.2  AP-3 complex subunit mu-2

    See identical proteins and their annotated locations for NP_083781.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK081220, BB610934
    Consensus CDS
    CCDS22184.1
    UniProtKB/Swiss-Prot
    Q3UYJ3, Q8R2R9, Q923G7
    Related
    ENSMUSP00000147967.2, ENSMUST00000210656.2
    Conserved Domains (2) summary
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
    cl10970
    Location:165 → 418
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    23277370..23297308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243706.1 → XP_030099566.1  AP-3 complex subunit mu-2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UYJ3, Q8R2R9, Q923G7
    Conserved Domains (2) summary
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
    cl10970
    Location:165 → 418
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2R9.1 GenPept UniProtKB/Swiss-Prot:Q8R2R9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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