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Kcnip1 potassium voltage-gated channel interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65023, updated on 18-Sep-2024

Summary

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Official Symbol
Kcnip1provided by RGD
Official Full Name
potassium voltage-gated channel interacting protein 1provided by RGD
Primary source
RGD:70886
See related
EnsemblRapid:ENSRNOG00000005365 AllianceGenome:RGD:70886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kchip1
Summary
Enables several functions, including calcium ion binding activity; protein N-terminus binding activity; and transmembrane transporter binding activity. Involved in positive regulation of action potential. Located in dendrite; neuronal cell body; and plasma membrane. Part of potassium channel complex. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 29.7), Testes (RPKM 11.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcnip1 in Genome Data Viewer
Location:
10q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (18723726..19093025, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (18219519..18588833, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18558128..18942677, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RAN binding protein 17 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene uncharacterized LOC108352198 Neighboring gene uncharacterized LOC120095244 Neighboring gene gamma-aminobutyric acid type A receptor subunit pi Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene uncharacterized LOC120095245 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 1 Neighboring gene uncharacterized LOC134480773 Neighboring gene similar to human chromosome 5 open reading frame 58 Neighboring gene lymphocyte cytosolic protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional properties of a brain-specific NH2-terminally spliced modulator of Kv4 channels. Boland LM, et al. Am J Physiol Cell Physiol, 2003 Jul. PMID 12646414
  2. Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure? Hilber K, et al. J Biol Chem, 2002 Oct 4. PMID 12138168
  3. Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells. Del Pino J, et al. Toxicology, 2015 Jul 3. PMID 25917026
  4. Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features. Van Schijndel JE, et al. Behav Brain Res, 2010 Mar 5. PMID 19896980
  5. Inhibitory effects of polyunsaturated fatty acids on Kv4/KChIP potassium channels. Boland LM, et al. Am J Physiol Cell Physiol, 2009 May. PMID 19261906, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KChIP1 plays a neuroprotective role against 4-AP acute induced cell death in primary hippocampal cells through regulation of Kv 4.3 and GABA transmission but this is lost after long term exposure.
    Title: Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells.
  2. This study demonistrared that the expression and function of KCHIP1 channels in neurons of the rat bed nucleus of the stria terminalis.
    Title: Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.
  3. KChIP1 is selectively expressed in BLA interneurons where it may function to regulate the activity of A-type potassium channels. Hence, KChIP1 might be considered as a specific regulator of GABAergic inhibitory circuits in the basolateral amygdala.
    Title: Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.
  4. Aph1b and KCnIP1 are significantly differentially expressed in a number of brain tissues of a schizophrenia model; KCnIP1 is an attractive novel candidate gene that may play a role in the complex phenotype
    Title: Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features.
  5. PUFAs inhibit Kv4/KChIP channels by facilitating inactivation from open and closed gating states and access of the fatty acid to the internal leaflet of the membrane is important
    Title: Inhibitory effects of polyunsaturated fatty acids on Kv4/KChIP potassium channels.
  6. KChIPs have an essential role in determining both the biophysical and molecular characteristics of Kv4 channels
    Title: A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.
  7. KChIP1 coassociates with Kv4 subunits in hippocampal membranes, confirming that the KChIPs are tightly associated with Kv4 subunits in native brain A-type channel complexes which may play a major role as modulators of somatodendritic excitability..
    Title: KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.
  8. The features of KChIP1b modulation of Kv4 channels are likely to be conserved in mammals and demonstrate a role for the KChIP1 NH2-terminal region in the regulation of closed inactivation gating.
    Title: Functional properties of a brain-specific NH2-terminally spliced modulator of Kv4 channels.
  9. hypothesis that occlusion of the inner vestibule of the Na(+) channel by the fast inactivation gate inhibits ultra-slow inactivation (mu1 sodium channel)
    Title: Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of action potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Kv4.3-KChIP1 channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of Kv4.3-KChIP1 channel complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
A-type potassium channel modulatory protein KCNIP1; Kv channel-interacting protein 1
Names
A-type potassium channel modulatory protein 1
potassium channel-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261387.1 → NP_001248316.1  A-type potassium channel modulatory protein KCNIP1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K701, A0A0H2UHE0, A0A0H2UHY1
    Related
    ENSRNOP00000046697.3, ENSRNOT00000040737.4
    Conserved Domains (2) summary
    COG5126
    Location:59 → 225
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:146 → 217
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001261388.1 → NP_001248317.1  A-type potassium channel modulatory protein KCNIP1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C- termini compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K701, A0A8I6ALG6
    Related
    ENSRNOP00000094374.1, ENSRNOT00000120110.2
    Conserved Domains (1) summary
    COG5126
    Location:48 → 214
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. NM_001261389.2 → NP_001248318.1  A-type potassium channel modulatory protein KCNIP1 isoform 3

    See identical proteins and their annotated locations for NP_001248318.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q793P9, Q8CIR1, Q8R425, Q8R426
    UniProtKB/TrEMBL
    A0A0G2K701
    Related
    ENSRNOP00000007187.5, ENSRNOT00000007187.7
    Conserved Domains (1) summary
    COG5126
    Location:50 → 216
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. NM_022929.3 → NP_075218.2  A-type potassium channel modulatory protein KCNIP1 isoform 4

    See identical proteins and their annotated locations for NP_075218.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K701, A6HDH0
    Related
    ENSRNOP00000074006.2, ENSRNOT00000083090.3
    Conserved Domains (1) summary
    COG5126
    Location:39 → 205
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    18723726..19093025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246105.5 → XP_006246167.1  Kv channel-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006246167.1

    UniProtKB/TrEMBL
    A0A0G2K0U3
    Related
    ENSRNOP00000071584.2, ENSRNOT00000079031.3
    Conserved Domains (1) summary
    COG5126
    Location:68 → 234
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R426.2 GenPept UniProtKB/Swiss-Prot:Q8R426

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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