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SLA Src like adaptor [ Homo sapiens (human) ]

Gene ID: 6503, updated on 2-Nov-2024

Summary

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Official Symbol
SLAprovided by HGNC
Official Full Name
Src like adaptorprovided by HGNC
Primary source
HGNC:HGNC:10902
See related
Ensembl:ENSG00000155926 MIM:601099; AllianceGenome:HGNC:10902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLA1; SLAP
Summary
Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in cytosol. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in appendix (RPKM 40.5), lymph node (RPKM 30.4) and 15 other tissues See more
Orthologs
mouse all
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Genomic context

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See SLA in Genome Data Viewer
Location:
8q24.22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (133036728..133102602, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (134160152..134225947, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (134048973..134114846, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene thyroglobulin Neighboring gene uncharacterized LOC105375768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27992 Neighboring gene ribosomal protein L21 pseudogene 78 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:134061257-134062456 Neighboring gene microRNA 7848 Neighboring gene papillary thyroid carcinoma susceptibility candidate 1 Neighboring gene uncharacterized LOC105375769 Neighboring gene NANOG hESC enhancer GRCh37_chr8:134157066-134157567 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:134194436-134195635 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:134204154-134204401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134208271-134208770 Neighboring gene uncharacterized LOC102723635 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:134224019-134225218 Neighboring gene cellular communication network factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid. Ohtsuki T, et al. Biochem Biophys Res Commun, 1997 Jan 3. PMID 9020066
  2. The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene. Meijerink PH, et al. Eur J Biochem, 1998 Jun 1. PMID 9660183
  3. Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia. Mansha M, et al. Leuk Res, 2010 Apr. PMID 19631983
  4. Intracellular cytoplasm-specific delivery of SH3 and SH2 domains of SLAP inhibits TcR-mediated signaling. Kim JH, et al. Biochem Biophys Res Commun, 2015 May 8. PMID 25800872
  5. Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse, fish, fly, and worm. Wang CX, et al. World J Gastroenterol, 2006 Feb 14. PMID 16521218, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLAP Is a Negative Regulator of FcepsilonRI Receptor-Mediated Signaling and Allergic Response.
    Title: SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response.
  2. results suggest that cytoplasm-specific transduction of the SH3 and SH2 domains of SLAP has a therapeutic potential of being an immunosuppressive reagent for the treatment of various autoimmune diseases
    Title: Intracellular cytoplasm-specific delivery of SH3 and SH2 domains of SLAP inhibits TcR-mediated signaling.
  3. Taken together the data demonstrate that SLAP negatively regulates wild-type c-Kit signaling, but not its oncogenic counterpart, indicating a possible mechanism by which the oncogenic c-Kit bypasses the normal cellular negative feedback control
    Title: Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling.
  4. upon ligand stimulation SLAP stably associates with Flt3 through multiple phosphotyrosine residues in Flt3. SLAP mRNA is differentially expressed in different cancers and its expression significantly increased in patients carrying the Flt3-ITD mutation
    Title: Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.
  5. These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling.
    Title: CD3ζ-chain expression of human T lymphocytes is regulated by TNF via Src-like adaptor protein-dependent proteasomal degradation.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Although SLA is a prominent glucocorticoids response gene, it does not seem to contribute to the anti-leukemic effects of glucocorticoids.
    Title: Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
  9. The SLA molecule and its functionally relevant residues have been highly conserved throughout the evolution.
    Title: Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse, fish, fly, and worm.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
EBI GWAS Catalog
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
EBI GWAS Catalog
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
src-like-adapter
Names
SLAP-1
hSLAP
src-like-adapter protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045556.3 → NP_001039021.1  src-like-adapter isoform a

    See identical proteins and their annotated locations for NP_001039021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (a).
    Source sequence(s)
    BX648382, D89077, DB265860, U44403
    Consensus CDS
    CCDS6370.1
    UniProtKB/Swiss-Prot
    B7Z4J2, B7Z4L6, Q13239, Q6FI01, Q9UMQ8
    UniProtKB/TrEMBL
    Q5TZW1
    Related
    ENSP00000337548.5, ENST00000338087.10
    Conserved Domains (2) summary
    cd10344
    Location:73 → 170
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:26 → 80
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

  2. NM_001045557.3 → NP_001039022.2  src-like-adapter isoform b

    See identical proteins and their annotated locations for NP_001039022.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon and uses an upstream translation initiation codon, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AF305872, BX648382, U44403
    Consensus CDS
    CCDS47922.1
    UniProtKB/TrEMBL
    Q5TZW1
    Related
    ENSP00000378759.3, ENST00000395352.7
    Conserved Domains (2) summary
    cd10344
    Location:90 → 187
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:43 → 97
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

  3. NM_001282964.2 → NP_001269893.1  src-like-adapter isoform d

    See identical proteins and their annotated locations for NP_001269893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the centtral coding region compared to variant 1. These differences result in the use of an upstream start codon compared to varian 1. The encoded isoform (d) is shorter but has an extended N-terminus compare to isoform a.
    Source sequence(s)
    AF305872, AK297423, AW137142
    Consensus CDS
    CCDS64978.1
    UniProtKB/TrEMBL
    Q5TZW1
    Related
    ENSP00000428559.1, ENST00000517648.5
    Conserved Domains (2) summary
    cd12010
    Location:43 → 97
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein
    cl15255
    Location:90 → 134
    SH2; Src homology 2 (SH2) domain

  4. NM_001282965.2 → NP_001269894.1  src-like-adapter isoform e

    See identical proteins and their annotated locations for NP_001269894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 5' UTR which results in the use of an downstream start codon compared to variant 1. The encodoed isoform (e) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AF305872, AK297519, AW137142
    Consensus CDS
    CCDS64977.1
    UniProtKB/Swiss-Prot
    Q13239
    Related
    ENSP00000427928.1, ENST00000524345.5
    Conserved Domains (1) summary
    cl15255
    Location:1 → 62
    SH2; Src homology 2 (SH2) domain

  5. NM_006748.4 → NP_006739.2  src-like-adapter isoform c

    See identical proteins and their annotated locations for NP_006739.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AF305872, BC007042, BX648382, DA999385, U44403
    Consensus CDS
    CCDS47923.1
    UniProtKB/TrEMBL
    Q5TZW1
    Related
    ENSP00000394049.2, ENST00000427060.6
    Conserved Domains (2) summary
    cd10344
    Location:113 → 210
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:66 → 120
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    133036728..133102602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422110.1 → XP_047278066.1  src-like-adapter isoform X3

  2. XM_047422107.1 → XP_047278063.1  src-like-adapter isoform X1

    UniProtKB/Swiss-Prot
    B7Z4J2, B7Z4L6, Q13239, Q6FI01, Q9UMQ8

  3. XM_047422108.1 → XP_047278064.1  src-like-adapter isoform X2

  4. XM_047422109.1 → XP_047278065.1  src-like-adapter isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    134160152..134225947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361024.1 → XP_054216999.1  src-like-adapter isoform X3

  2. XM_054361021.1 → XP_054216996.1  src-like-adapter isoform X1

    UniProtKB/Swiss-Prot
    B7Z4J2, B7Z4L6, Q13239, Q6FI01, Q9UMQ8

  3. XM_054361022.1 → XP_054216997.1  src-like-adapter isoform X2

  4. XM_054361023.1 → XP_054216998.1  src-like-adapter isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13239.3 GenPept UniProtKB/Swiss-Prot:Q13239

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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