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Doc2a double C2 domain alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 65031, updated on 28-Oct-2024

Summary

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Official Symbol
Doc2aprovided by RGD
Official Full Name
double C2 domain alphaprovided by RGD
Primary source
RGD:620518
See related
EnsemblRapid:ENSRNOG00000019920 AllianceGenome:RGD:620518
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium-dependent phospholipid binding activity and metal ion binding activity. Involved in calcium-dependent activation of synaptic vesicle fusion. Located in lysosome. Is active in glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human DOC2A (double C2 domain alpha). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 76.8), Adrenal (RPKM 37.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Doc2a in Genome Data Viewer
Location:
1q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190887306..190893057)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181457415..181462528)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198282828..198288611)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TLC domain containing 3B Neighboring gene uncharacterized LOC134483857 Neighboring gene similar to human chromosome 16 open reading frame 92 Neighboring gene INO80 complex subunit E Neighboring gene HIRA interacting protein 3 Neighboring gene TAO kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development. Korteweg N, et al. Eur J Neurosci, 2000 Jan. PMID 10651871
  2. Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain. Naito A, et al. Brain Res Mol Brain Res, 1997 Mar. PMID 9073161
  3. DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion. Verhage M, et al. Neuron, 1997 Mar. PMID 9115738
  4. Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Yao J, et al. Cell, 2011 Oct 28. PMID 22036572, Free PMC Article
  5. Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. Higashio H, et al. J Immunol, 2008 Apr 1. PMID 18354201

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent activation of synaptic vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spontaneous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle exocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
double C2-like domain-containing protein alpha
Names
doc2-alpha
double C2, alpha
double C2-like domains, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022937.3 → NP_075226.1  double C2-like domain-containing protein alpha

    See identical proteins and their annotated locations for NP_075226.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P70611
    UniProtKB/TrEMBL
    A6I9G0
    Conserved Domains (2) summary
    cd04035
    Location:93 → 216
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:257 → 389
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    190887306..190893057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272851.1 → XP_063128921.1  double C2-like domain-containing protein alpha isoform X1

    UniProtKB/Swiss-Prot
    P70611
    UniProtKB/TrEMBL
    A6I9G0

  2. XM_006230335.5 → XP_006230397.1  double C2-like domain-containing protein alpha isoform X1

    See identical proteins and their annotated locations for XP_006230397.1

    UniProtKB/Swiss-Prot
    P70611
    UniProtKB/TrEMBL
    A6I9G0
    Conserved Domains (2) summary
    cd04035
    Location:93 → 216
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:257 → 389
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

  3. XM_006230339.5 → XP_006230401.1  double C2-like domain-containing protein alpha isoform X1

    See identical proteins and their annotated locations for XP_006230401.1

    UniProtKB/Swiss-Prot
    P70611
    UniProtKB/TrEMBL
    A6I9G0
    Conserved Domains (2) summary
    cd04035
    Location:93 → 216
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:257 → 389
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

  4. XM_006230337.5 → XP_006230399.1  double C2-like domain-containing protein alpha isoform X1

    See identical proteins and their annotated locations for XP_006230399.1

    UniProtKB/Swiss-Prot
    P70611
    UniProtKB/TrEMBL
    A6I9G0
    Conserved Domains (2) summary
    cd04035
    Location:93 → 216
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:257 → 389
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

  5. XM_006230340.3 → XP_006230402.1  double C2-like domain-containing protein alpha isoform X1

    See identical proteins and their annotated locations for XP_006230402.1

    UniProtKB/Swiss-Prot
    P70611
    UniProtKB/TrEMBL
    A6I9G0
    Conserved Domains (2) summary
    cd04035
    Location:93 → 216
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:257 → 389
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

  6. XM_006230336.3 → XP_006230398.1  double C2-like domain-containing protein alpha isoform X1

    See identical proteins and their annotated locations for XP_006230398.1

    UniProtKB/Swiss-Prot
    P70611
    UniProtKB/TrEMBL
    A6I9G0
    Related
    ENSRNOP00000027022.2, ENSRNOT00000027022.6
    Conserved Domains (2) summary
    cd04035
    Location:93 → 216
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:257 → 389
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

  7. XM_039089802.2 → XP_038945730.1  double C2-like domain-containing protein alpha isoform X1

    UniProtKB/Swiss-Prot
    P70611
    UniProtKB/TrEMBL
    A6I9G0
    Conserved Domains (2) summary
    cd04035
    Location:93 → 216
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:257 → 389
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70611.1 GenPept UniProtKB/Swiss-Prot:P70611

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