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RSRC2 arginine and serine rich coiled-coil 2 [ Homo sapiens (human) ]

Gene ID: 65117, updated on 3-Nov-2024

Summary

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Official Symbol
RSRC2provided by HGNC
Official Full Name
arginine and serine rich coiled-coil 2provided by HGNC
Primary source
HGNC:HGNC:30559
See related
Ensembl:ENSG00000111011 MIM:619996; AllianceGenome:HGNC:30559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 73.5), testis (RPKM 24.5) and 25 other tissues See more
Orthologs
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Genomic context

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See RSRC2 in Genome Data Viewer
Location:
12q24.31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (122503454..122526936, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (122499260..122522407, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (122988001..123011483, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CAP-Gly domain containing linker protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122885121-122885806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122885807-122886492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7219 Neighboring gene CLIP1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122916171-122916672 Neighboring gene Sharpr-MPRA regulatory region 9757 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122927953-122928453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122984447-122985138 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:122985139-122985832 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:122985833-122986524 Neighboring gene MPRA-validated peak2019 silencer Neighboring gene zinc finger CCHC-type containing 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7231 Neighboring gene kinetochore associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:123122624-123123524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7235 Neighboring gene uncharacterized LOC124903124

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel gene, RSRC2, inhibits cell proliferation and affects survival in esophageal cancer patients. Kurehara H, et al. Int J Oncol, 2007 Feb. PMID 17203224
  2. TRA2A Promoted Paclitaxel Resistance and Tumor Progression in Triple-Negative Breast Cancers via Regulating Alternative Splicing. Liu T, et al. Mol Cancer Ther, 2017 Jul. PMID 28416606
  3. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Rahman S, et al. Mol Cell Biol, 2011 Jul. PMID 21555454, Free PMC Article
  4. KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Kumar A, et al. Cell Rep, 2022 May 10. PMID 35545047, Free PMC Article
  5. Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. Gallardo-Vara E, et al. Cells, 2019 Sep 13. PMID 31540324, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11021

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
arginine/serine-rich coiled-coil protein 2
Names
arginine/serine-rich coiled-coil 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023012.6 → NP_075388.2  arginine/serine-rich coiled-coil protein 2

    See identical proteins and their annotated locations for NP_075388.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the shortest transcript but encodes a functional protein.
    Source sequence(s)
    AB212664, AC127002
    Consensus CDS
    CCDS31920.1
    UniProtKB/Swiss-Prot
    Q6N040, Q6NW16, Q7L4I2, Q9H864
    Related
    ENSP00000330188.6, ENST00000331738.12
    Conserved Domains (1) summary
    pfam15477
    Location:354 → 423
    SMAP; Small acidic protein family

RNA

  1. NR_036434.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an additional exon in the CDS compared to variant 1. The exon includes a premature stop codon, so this variant is a nonsense-mediated mRNA decay candidate and does not make a functional protein.
    Source sequence(s)
    AC127002, AK094465, BC008684

  2. NR_036435.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon and an additional segment in the CDS compared to variant 1. The exon includes a premature stop codon, so this variant is a nonsense-mediated mRNA decay candidate and does not make a functional protein.
    Source sequence(s)
    AC127002, DB081070

  3. NR_036436.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an additional segment in the CDS compared to variant 1. The segment includes a premature stop codon, so this variant is a nonsense-mediated mRNA decay candidate and does not make a functional protein.
    Source sequence(s)
    AB212664, AC127002, BX647884

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    122503454..122526936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019830.3 → XP_016875319.1  arginine/serine-rich coiled-coil protein 2 isoform X3

  2. XM_011538688.3 → XP_011536990.1  arginine/serine-rich coiled-coil protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15477
    Location:342 → 394
    SMAP; Small acidic protein family

  3. XM_005253601.3 → XP_005253658.1  arginine/serine-rich coiled-coil protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005253658.1

    Conserved Domains (1) summary
    pfam15477
    Location:355 → 424
    SMAP; Small acidic protein family

  4. XM_047429371.1 → XP_047285327.1  arginine/serine-rich coiled-coil protein 2 isoform X7

  5. XM_005253602.3 → XP_005253659.1  arginine/serine-rich coiled-coil protein 2 isoform X4

    Conserved Domains (1) summary
    pfam15477
    Location:307 → 376
    SMAP; Small acidic protein family

  6. XM_047429372.1 → XP_047285328.1  arginine/serine-rich coiled-coil protein 2 isoform X8

  7. XM_047429370.1 → XP_047285326.1  arginine/serine-rich coiled-coil protein 2 isoform X6

  8. XM_047429369.1 → XP_047285325.1  arginine/serine-rich coiled-coil protein 2 isoform X5

  9. XM_047429373.1 → XP_047285329.1  arginine/serine-rich coiled-coil protein 2 isoform X9

RNA

  1. XR_007063114.1 RNA Sequence

  2. XR_007063115.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    122499260..122522407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372926.1 → XP_054228901.1  arginine/serine-rich coiled-coil protein 2 isoform X3

  2. XM_054372925.1 → XP_054228900.1  arginine/serine-rich coiled-coil protein 2 isoform X2

  3. XM_054372924.1 → XP_054228899.1  arginine/serine-rich coiled-coil protein 2 isoform X1

  4. XM_054372927.1 → XP_054228902.1  arginine/serine-rich coiled-coil protein 2 isoform X4

  5. XM_054372933.1 → XP_054228908.1  arginine/serine-rich coiled-coil protein 2 isoform X11

  6. XM_054372932.1 → XP_054228907.1  arginine/serine-rich coiled-coil protein 2 isoform X10

    UniProtKB/TrEMBL
    B3KMH4

  7. XM_054372930.1 → XP_054228905.1  arginine/serine-rich coiled-coil protein 2 isoform X8

  8. XM_054372929.1 → XP_054228904.1  arginine/serine-rich coiled-coil protein 2 isoform X6

  9. XM_054372928.1 → XP_054228903.1  arginine/serine-rich coiled-coil protein 2 isoform X5

  10. XM_054372931.1 → XP_054228906.1  arginine/serine-rich coiled-coil protein 2 isoform X9

RNA

  1. XR_008488664.1 RNA Sequence

  2. XR_008488665.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198261.2: Suppressed sequence

    Description
    NM_198261.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_198262.2: Suppressed sequence

    Description
    NM_198262.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L4I2.1 GenPept UniProtKB/Swiss-Prot:Q7L4I2

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