Sec11a SEC11 homolog A, signal peptidase complex subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sec11aprovided by RGD
Official Full Name: SEC11 homolog A, signal peptidase complex subunitprovided by RGD
Primary source: RGD:69360
See related: EnsemblRapid:ENSRNOG00000011029 AllianceGenome:RGD:69360
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spc18; Sec11l1
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Orthologous to human SEC11A (SEC11 homolog A, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 290.0), Lung (RPKM 282.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (144290680..144318658, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (134881448..134909427, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (142733423..142759999, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129975 (e-PCR)
- UniSTS:213263

RH131101 (e-PCR)
- UniSTS:214384

RH140931 (e-PCR)
- UniSTS:214384

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	IEA Inferred from Electronic Annotation more info
involved_in signal peptide processing	ISO Inferred from Sequence Orthology more info
involved_in signal peptide processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
part_of signal peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of signal peptidase complex	IEA Inferred from Electronic Annotation more info
part_of signal peptidase complex	ISO Inferred from Sequence Orthology more info
part_of signal peptidase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: signal peptidase complex catalytic subunit SEC11A

Names: SEC11-like protein 1; SPase 18 kDa subunit; Sec11-like 1; endopeptidase SP18; microsomal signal peptidase 18 kDa subunit; signal peptidase complex 18kD

NP_113911.2

EC 3.4.21.89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031723.3 → NP_113911.2 signal peptidase complex catalytic subunit SEC11A

See identical proteins and their annotated locations for NP_113911.2

Status: PROVISIONAL

Source sequence(s)

BC060554

UniProtKB/Swiss-Prot

P42667

UniProtKB/TrEMBL

F1LMT3, Q6P9X2

Related

ENSRNOP00000076819.2, ENSRNOT00000095961.2

Conserved Domains (1) summary

cl10465
Location:38 → 150

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...