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Scamp3 secretory carrier membrane protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65169, updated on 14-Nov-2024

Summary

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Official Symbol
Scamp3provided by RGD
Official Full Name
secretory carrier membrane protein 3provided by RGD
Primary source
RGD:68351
See related
EnsemblRapid:ENSRNOG00000020500 AllianceGenome:RGD:68351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein phosphorylation and protein transport. Predicted to act upstream of or within response to retinoic acid. Predicted to be located in Golgi membrane. Orthologous to several human genes including CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 183.1), Thymus (RPKM 146.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Scamp3 in Genome Data Viewer
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176880873..176886750)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174583124..174588984)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188488907..188495147)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene pyruvate kinase L/R Neighboring gene hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Neighboring gene CDC-like kinase 2 Neighboring gene microRNA 3541 Neighboring gene endosomal transmembrane epsin interactor 3 Neighboring gene uncharacterized LOC102550011 Neighboring gene glucosylceramidase beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis. Liao H, et al. Am J Physiol Cell Physiol, 2008 Mar. PMID 18171723
  2. Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions. Fernández-Chacón R, et al. J Neurosci, 2000 Nov 1. PMID 11050114, Free PMC Article
  3. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. Smith CJ, et al. J Cell Sci, 2013 Mar 15. PMID 23418353
  4. Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. Kunarso G, et al. BMC Genomics, 2008 Apr 9. PMID 18400104, Free PMC Article
  5. Proteomics characterization of abundant Golgi membrane proteins. Bell AW, et al. J Biol Chem, 2001 Feb 16. PMID 11042173

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCAMP isoforms regulate membrane fusion and dense core vesicle exocytosis in neurons.
    Title: Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
secretory carrier-associated membrane protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031724.1 → NP_113912.1  secretory carrier-associated membrane protein 3

    Status: VALIDATED

    Source sequence(s)
    BQ783359, CK599635, DV726194
    UniProtKB/TrEMBL
    A0A8I6GC12, E9PTW1
    Related
    ENSRNOP00000027815.6, ENSRNOT00000027815.8
    Conserved Domains (1) summary
    pfam04144
    Location:135 → 310
    SCAMP; SCAMP family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    176880873..176886750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232753.5 → XP_006232815.1  secretory carrier-associated membrane protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006232815.1

    UniProtKB/TrEMBL
    A0A8I6GC12, A6J6C4
    Related
    ENSRNOP00000084600.1, ENSRNOT00000111900.2
    Conserved Domains (1) summary
    pfam04144
    Location:134 → 309
    SCAMP; SCAMP family

  2. XM_006232754.5 → XP_006232816.1  secretory carrier-associated membrane protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GC12
    Conserved Domains (1) summary
    pfam04144
    Location:94 → 269
    SCAMP; SCAMP family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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