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Stk3 serine/threonine kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65189, updated on 2-Nov-2024

Summary

Official Symbol
Stk3provided by RGD
Official Full Name
serine/threonine kinase 3provided by RGD
Primary source
RGD:68412
See related
EnsemblRapid:ENSRNOG00000011278 AllianceGenome:RGD:68412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MST2
Summary
Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and transcription regulator activator activity. Predicted to be involved in several processes, including hippo signaling; protein localization to organelle; and regulation of signal transduction. Predicted to act upstream of or within several processes, including chordate embryonic development; hepatocyte apoptotic process; and positive regulation of signal transduction. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human STK3 (serine/threonine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 64.2), Adrenal (RPKM 61.7) and 9 other tissues See more
Orthologs
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Genomic context

See Stk3 in Genome Data Viewer
Location:
7q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (67938341..68208472, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (66053209..66323292, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (73617926..73883896, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553465 Neighboring gene potassium voltage-gated channel, modifier subfamily S, member 2 Neighboring gene odd-skipped related transciption factor 2 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription regulator activator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription regulator activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation involved in embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within central nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in endocardium development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endocardium development ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube formation ISO
Inferred from Sequence Orthology
more info
 
involved_in organ growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of organ growth ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hippo signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in primitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within primitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell differentiation involved in embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 3
Names
MST-2
STE20-like kinase MST2
mammalian STE20-like protein kinase 2
serine/threonine kinase 3 (STE20 homolog, yeast)
NP_113923.2
XP_008763681.1
XP_008763684.1
XP_038935793.1
XP_038935794.1
XP_038935795.1
XP_063120292.1
XP_063120293.1
XP_063120294.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031735.2NP_113923.2  serine/threonine-protein kinase 3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    O54748
    UniProtKB/TrEMBL
    B1WBQ5, F7ER57
    Related
    ENSRNOP00000062778.1, ENSRNOT00000065722.5
    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    pfam11629
    Location:437484
    Mst1_SARAH; C terminal SARAH domain of Mst1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    67938341..68208472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765462.4XP_008763684.1  serine/threonine-protein kinase 3 isoform X6

    Conserved Domains (3) summary
    smart00220
    Location:27167
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:326373
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:23167
    PKc_like; Protein Kinases, catalytic domain
  2. XM_039079866.2XP_038935794.1  serine/threonine-protein kinase 3 isoform X5

    Conserved Domains (2) summary
    pfam11629
    Location:370414
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:23167
    PKc_like; Protein Kinases, catalytic domain
  3. XM_039079865.2XP_038935793.1  serine/threonine-protein kinase 3 isoform X1

    UniProtKB/Swiss-Prot
    O54748
    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    pfam11629
    Location:481525
    Mst1_SARAH; C terminal SARAH domain of Mst1
  4. XM_063264222.1XP_063120292.1  serine/threonine-protein kinase 3 isoform X3

  5. XM_039079867.1XP_038935795.1  serine/threonine-protein kinase 3 isoform X7

    Conserved Domains (2) summary
    pfam11629
    Location:250294
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:147
    PKc_like; Protein Kinases, catalytic domain
  6. XM_063264223.1XP_063120293.1  serine/threonine-protein kinase 3 isoform X4

  7. XM_008765459.4XP_008763681.1  serine/threonine-protein kinase 3 isoform X2

    UniProtKB/Swiss-Prot
    O54748
    Related
    ENSRNOP00000107813.1, ENSRNOT00000131594.1
    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  8. XM_063264224.1XP_063120294.1  serine/threonine-protein kinase 3 isoform X8