Slc29a2 solute carrier family 29 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Slc29a2provided by RGD
Full Name: solute carrier family 29 member 2provided by RGD
Primary source: RGD:69296
See related: Ensembl:ENSRNOG00000020025 AllianceGenome:RGD:69296
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rENT2
Summary: Enables nucleoside transmembrane transporter activity. Involved in several processes, including lactation; nucleobase transport; and uridine transport. Predicted to be located in presynapse. Predicted to be integral component of plasma membrane. Predicted to be active in basolateral plasma membrane. Predicted to be integral component of membrane. Orthologous to human SLC29A2 (solute carrier family 29 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 31.7), Adrenal (RPKM 25.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (211756588..211764561)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (202327641..202335185)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (220306622..220314631)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ENT2 appears to be the mediator of fluorouracil transport in rat placental trophoblast cells.
Title: Contribution of equilibrative nucleoside transporter (ENT) 2 to fluorouracil transport in rat placental trophoblast cells.
The purpose of this study is to determine the localization of nucleoside transporters expressed within rat epididymis to demonstrate the potential of epididymal reabsorption. Using immunohistochemistry, we determined that equilibrative nucleoside transporter 1 (ENT1) is localized to the basolateral membrane of epithelial cells, ENT2 is expressed in the nucleus of the epithelium and CNT2 is expressed by basal cells.
Title: Localization of nucleoside transporters in rat epididymis.
ENT2 mediates both the influx and efflux of hypoxanthine in rat microvascular endothelial cells.
Title: Hypoxanthine uptake and release by equilibrative nucleoside transporter 2 (ENT2) of rat microvascular endothelial cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adenine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables adenine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables adenine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables cytidine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables cytidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cytidine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables guanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables guanine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleobase transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleobase transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleobase transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables purine nucleoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables purine nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uracil transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uracil transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uracil transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables uridine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uridine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in adenine transport	IEA Inferred from Electronic Annotation more info
involved_in adenine transport	ISO Inferred from Sequence Orthology more info
involved_in adenosine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in adenosine transport	IEA Inferred from Electronic Annotation more info
involved_in adenosine transport	ISO Inferred from Sequence Orthology more info
involved_in adenosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytidine transport	IEA Inferred from Electronic Annotation more info
involved_in cytidine transport	ISO Inferred from Sequence Orthology more info
involved_in cytidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in guanine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in guanine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in guanine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hypoxanthine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in hypoxanthine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in hypoxanthine transport	IEA Inferred from Electronic Annotation more info
involved_in hypoxanthine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hypoxanthine transport	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in inosine transport	IEA Inferred from Electronic Annotation more info
involved_in inosine transport	ISO Inferred from Sequence Orthology more info
involved_in inosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter uptake	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in nucleobase transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleobase transport	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nucleoside transport	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine nucleoside transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in purine nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine-containing compound transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thymine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thymine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in thymine transport	IEA Inferred from Electronic Annotation more info
involved_in thymine transport	ISO Inferred from Sequence Orthology more info
involved_in uracil transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uracil transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uracil transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in uridine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in uridine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in uridine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uridine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: equilibrative nucleoside transporter 2

Names: equilibrative NBMPR-insensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; nucleoside transporter, ei-type; solute carrier family 29 (equilibrative nucleoside transporter), member 2; solute carrier family 29 (nucleoside transporters), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031738.1 → NP_113926.1 equilibrative nucleoside transporter 2

See identical proteins and their annotated locations for NP_113926.1

Status: PROVISIONAL

Source sequence(s)

AF015305

UniProtKB/Swiss-Prot

O54699

UniProtKB/TrEMBL

A6HZ13

Conserved Domains (1) summary

TIGR00939
Location:18 → 456

2a57; Equilibrative Nucleoside Transporter (ENT)