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B4galt6 beta-1,4-galactosyltransferase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65196, updated on 2-Nov-2024

Summary

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Official Symbol
B4galt6provided by RGD
Official Full Name
beta-1,4-galactosyltransferase 6provided by RGD
Primary source
RGD:71046
See related
EnsemblRapid:ENSRNOG00000015895 AllianceGenome:RGD:71046
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT6 (beta-1,4-galactosyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 145.5), Lung (RPKM 121.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See B4galt6 in Genome Data Viewer
Location:
18p12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (12233350..12290204, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (11958382..12015247, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (15462913..15525584)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551809 Neighboring gene transthyretin Neighboring gene uncharacterized LOC102551486 Neighboring gene importin 5, pseudogene 1 Neighboring gene uncharacterized LOC120098272

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. cDNA cloning and expression of human lactosylceramide synthase. Takizawa M, et al. Biochim Biophys Acta, 1999 May 18. PMID 10320813
  2. Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. Nomura T, et al. J Biol Chem, 1998 May 29. PMID 9593693
  3. Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. Yoshihara T, et al. PLoS Genet, 2018 Aug. PMID 30114188, Free PMC Article
  4. Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs. Yamaji T, et al. PLoS One, 2014. PMID 24498430, Free PMC Article
  5. β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5. Tokuda N, et al. Glycobiology, 2013 Oct. PMID 23882130

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in central nervous system neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system neuron axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycosphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lactosylceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 6
Names
LacCer synthase
Lactosylceramide Synthase
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6
b4Gal-T6
beta-1,4-GalTase 6
beta4Gal-T6
glucosylceramide beta-1,4-galactosyltransferase
NP_113928.1
XP_038953013.1
XP_038953015.1
XP_038953016.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031740.3 → NP_113928.1  beta-1,4-galactosyltransferase 6

    See identical proteins and their annotated locations for NP_113928.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    O88419
    UniProtKB/TrEMBL
    A6J2G4
    Related
    ENSRNOP00000082568.1, ENSRNOT00000111678.2
    Conserved Domains (1) summary
    cd00899
    Location:155 → 371
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    12233350..12290204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097085.2 → XP_038953013.1  beta-1,4-galactosyltransferase 6 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MXX9
    Conserved Domains (1) summary
    cd00899
    Location:130 → 346
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  2. XM_039097087.2 → XP_038953015.1  beta-1,4-galactosyltransferase 6 isoform X2

    Conserved Domains (1) summary
    cd00899
    Location:111 → 327
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  3. XM_039097088.2 → XP_038953016.1  beta-1,4-galactosyltransferase 6 isoform X2

    Related
    ENSRNOP00000021764.8, ENSRNOT00000021764.9
    Conserved Domains (1) summary
    cd00899
    Location:111 → 327
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88419.1 GenPept UniProtKB/Swiss-Prot:O88419

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