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Asb3 ankyrin repeat and SOCS box-containing 3 [ Mus musculus (house mouse) ]

Gene ID: 65257, updated on 2-Nov-2024

Summary

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Official Symbol
Asb3provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 3provided by MGI
Primary source
MGI:MGI:1929749
See related
Ensembl:ENSMUSG00000020305 AllianceGenome:MGI:1929749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asb-3; 2400011J03Rik
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Is expressed in cerebral cortex; cerebral cortex ventricular layer; and trunk somite. Orthologous to human GPR75-ASB3 (GPR75-ASB3 readthrough) and ASB3 (ankyrin repeat and SOCS box containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.5), CNS E18 (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Asb3 in Genome Data Viewer
Location:
11 A4; 11 18.19 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30904398..31052704)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30954392..31102704)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene G protein-coupled receptor 75 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene ChaC, cation transport regulator 2 Neighboring gene STARR-seq mESC enhancer starr_29073 Neighboring gene GPN-loop GTPase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29074 Neighboring gene STARR-seq mESC enhancer starr_29075 Neighboring gene STARR-seq mESC enhancer starr_29076 Neighboring gene predicted gene, 40822 Neighboring gene stanniocalcin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota. Cheng M, et al. mBio, 2024 Sep 11. PMID 39162488, Free PMC Article
  2. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. Kile BT, et al. Gene, 2000 Nov 27. PMID 11111040
  3. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
  4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.
    Title: ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 3
Names
ankyrin repeat and SOCS box-containing protein 3
ankyrin repeat-containing SOCS box protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023906.3 → NP_076395.2  ankyrin repeat and SOCS box protein 3

    See identical proteins and their annotated locations for NP_076395.2

    Status: VALIDATED

    Source sequence(s)
    AK028489, AK143580, BB618690
    Consensus CDS
    CCDS24511.1
    UniProtKB/Swiss-Prot
    Q5SSV5, Q9WV72
    UniProtKB/TrEMBL
    Q8R5B4
    Related
    ENSMUSP00000020551.7, ENSMUST00000020551.13
    Conserved Domains (4) summary
    cd03722
    Location:458 → 508
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:145 → 176
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:216 → 309
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:22 → 237
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    30904398..31052704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156890.1 → XP_036012783.1  ankyrin repeat and SOCS box protein 3 isoform X2

    Conserved Domains (3) summary
    cd03722
    Location:315 → 365
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:2 → 33
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:7 → 97
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006514771.5 → XP_006514834.1  ankyrin repeat and SOCS box protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006514834.1

    UniProtKB/Swiss-Prot
    Q5SSV5, Q9WV72
    UniProtKB/TrEMBL
    Q8R5B4
    Related
    ENSMUSP00000144900.2, ENSMUST00000203878.3
    Conserved Domains (4) summary
    cd03722
    Location:458 → 508
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:145 → 176
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:216 → 309
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:22 → 237
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV72.2 GenPept UniProtKB/Swiss-Prot:Q9WV72

Gene LinkOut

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