Mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mgat5provided by RGD
Full Name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferaseprovided by RGD
Primary source: RGD:620100
See related: EnsemblRapid:ENSRNOG00000003614 AllianceGenome:RGD:620100
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity; manganese ion binding activity; and protein phosphatase inhibitor activity. Predicted to be involved in several processes, including negative regulation of protein tyrosine phosphatase activity; positive regulation of receptor signaling pathway via STAT; and protein N-linked glycosylation via asparagine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Used to study proteinuria. Orthologous to human MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 147.1), Brain (RPKM 101.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q12-q13

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (41228327..41516462)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (38675776..38959697)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (43850744..44157860)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression.
Title: GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression.
These results strongly suggest that N-acetylglucosaminyltransferase V functioning as a specific endogenous role of NGF receptor function, which appear to be due, at least in part, to the promotion of differentiation.
Title: N-acetylglucosaminyltransferase V modifies TrKA protein, regulates the receptor function.

Submit: New GeneRIF Correction

General gene information

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Markers

D13Hmgc40 (e-PCR)
- UniSTS:530700

RH139379 (e-PCR)
- UniSTS:221465

D13Got18 (e-PCR)
- UniSTS:112478

STS-Z41143 (e-PCR)
- UniSTS:72298

BI292164 (e-PCR)
- UniSTS:245151

D13Got17 (e-PCR)
- UniSTS:114850

D13Got11 (e-PCR)
- UniSTS:112816

D13Rat174 (e-PCR), detects polymorphism
- UniSTS:226549

BF387978 (e-PCR)
- UniSTS:244479

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

Names: GNT-V; N-acetylglucosaminyl-transferase V; N-acetylglucosaminyltransferase V; alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A-like; alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; glcNAc-T V; mannoside acetylglucosaminyltransferase 5; mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase

NP_075583.1

EC 2.4.1.155

XP_017454423.1

EC 2.4.1.155

XP_038947016.1

EC 2.4.1.155

XP_063128664.1

EC 2.4.1.155

XP_063128665.1

EC 2.4.1.155

XP_063128666.1

EC 2.4.1.155

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023095.1 → NP_075583.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

See identical proteins and their annotated locations for NP_075583.1

Status: PROVISIONAL

Source sequence(s)

L14284

UniProtKB/Swiss-Prot

Q08834

UniProtKB/TrEMBL

A9CMA3, A9CMD1

Related

ENSRNOP00000004995.2, ENSRNOT00000004995.6

Conserved Domains (2) summary

pfam15024
Location:171 → 725

Glyco_transf_18; Glycosyltransferase family 18

pfam15027
Location:3 → 137

DUF4525; Domain of unknown function (DUF4525)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

41228327..41516462

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091088.2 → XP_038947016.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X2

Conserved Domains (2) summary

pfam15027
Location:7 → 137

DUF4525; Domain of unknown function (DUF4525)

pfam15024
Location:171 → 459

Glyco_transf_18; Glycosyltransferase family 18
XM_017598934.3 → XP_017454423.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X1

UniProtKB/Swiss-Prot

Q08834

UniProtKB/TrEMBL

A9CMA3, A9CMD1

Related

ENSRNOP00000076422.1, ENSRNOT00000100469.2

Conserved Domains (2) summary

pfam15024
Location:171 → 725

Glyco_transf_18; Glycosyltransferase family 18

pfam15027
Location:3 → 137

DUF4525; Domain of unknown function (DUF4525)
XM_063272594.1 → XP_063128664.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X1

UniProtKB/Swiss-Prot

Q08834

UniProtKB/TrEMBL

A9CMA3, A9CMD1
XM_063272596.1 → XP_063128666.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X1

UniProtKB/Swiss-Prot

Q08834

UniProtKB/TrEMBL

A9CMA3, A9CMD1
XM_063272595.1 → XP_063128665.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X1

UniProtKB/Swiss-Prot

Q08834

UniProtKB/TrEMBL

A9CMA3, A9CMD1