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Rnf130 ring finger protein 130 [ Rattus norvegicus (Norway rat) ]

Gene ID: 652955, updated on 10-Jul-2024

Summary

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Official Symbol
Rnf130provided by RGD
Official Full Name
ring finger protein 130provided by RGD
Primary source
RGD:1562041
See related
EnsemblRapid:ENSRNOG00000046330 AllianceGenome:RGD:1562041
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in programmed cell death and ubiquitin-dependent protein catabolic process. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Orthologous to human RNF130 (ring finger protein 130). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 384.9), Kidney (RPKM 325.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf130 in Genome Data Viewer
Location:
10q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (34843920..34957130)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34342835..34456048)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35537976..35610711)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 9 Neighboring gene uncharacterized LOC120095089 Neighboring gene RasGEF domain family, member 1C Neighboring gene microRNA 340-1 Neighboring gene TBC1 domain family member 9B Neighboring gene uncharacterized LOC120095090 Neighboring gene MRN complex interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing hormone/human chorionic gonadotropin in rat leydig cells. Guais A, et al. Biol Reprod, 2004 Jan. PMID 13679316
  2. Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1. Baker SJ, et al. Gene, 2000 May 2. PMID 10806348
  3. h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. Guais A, et al. Gene, 2006 Jun 7. PMID 16549277
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in programmed cell death ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF130
Names
R-goliath
goliath homolog
NP_001032747.1
XP_038942740.1
XP_038942741.1
XP_038942742.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037658.2 → NP_001032747.1  E3 ubiquitin-protein ligase RNF130 precursor

    See identical proteins and their annotated locations for NP_001032747.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q6Y290
    UniProtKB/TrEMBL
    B2GVA8
    Related
    ENSRNOP00000099640.1, ENSRNOT00000123844.1
    Conserved Domains (2) summary
    cd02122
    Location:40 → 179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:262 → 305
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    34843920..34957130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086813.1 → XP_038942741.1  E3 ubiquitin-protein ligase RNF130 isoform X2

    UniProtKB/TrEMBL
    A0A8I5XWR0
    Related
    ENSRNOP00000107484.1, ENSRNOT00000141833.1
    Conserved Domains (3) summary
    COG5243
    Location:197 → 414
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd02122
    Location:40 → 179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16803
    Location:262 → 310
    RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

  2. XM_039086814.2 → XP_038942742.1  E3 ubiquitin-protein ligase RNF130 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ATJ8, M0R971
    Related
    ENSRNOP00000066033.3, ENSRNOT00000071917.4
    Conserved Domains (3) summary
    COG5243
    Location:197 → 366
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd02122
    Location:40 → 179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16803
    Location:262 → 310
    RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

  3. XM_039086812.2 → XP_038942740.1  E3 ubiquitin-protein ligase RNF130 isoform X1

    Conserved Domains (3) summary
    COG5243
    Location:197 → 366
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd02122
    Location:40 → 179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16803
    Location:262 → 310
    RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Y290.1 GenPept UniProtKB/Swiss-Prot:Q6Y290

Gene LinkOut

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