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MATCAP1 microtubule associated tyrosine carboxypeptidase 1 [ Homo sapiens (human) ]

Gene ID: 653319, updated on 2-Nov-2024

Summary

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Official Symbol
MATCAP1provided by HGNC
Official Full Name
microtubule associated tyrosine carboxypeptidase 1provided by HGNC
Primary source
HGNC:HGNC:34408
See related
Ensembl:ENSG00000196123 MIM:619978; AllianceGenome:HGNC:34408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMCP1; KIAA0895L
Summary
Enables tubulin-tyrosine carboxypeptidase. Predicted to be involved in brain development. Is active in microtubule. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 12.4), adrenal (RPKM 12.1) and 25 other tissues See more
Orthologs
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Genomic context

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See MATCAP1 in Genome Data Viewer
Location:
16q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67175599..67183963, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72969893..72978247, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67209502..67217866, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67189519-67190420 Neighboring gene TNFRSF1A associated via death domain Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67195788-67196300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67196374-67197322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67197323-67198271 Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene Sharpr-MPRA regulatory region 11796 Neighboring gene heat shock transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7588 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67206328-67206491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67207408-67208330 Neighboring gene nucleolar protein 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67209861-67210290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67211873-67212416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67212417-67212958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10956 Neighboring gene exocyst complex component 3 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67225781-67226711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10958 Neighboring gene E2F transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7593

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation. Nicot S, et al. Sci Adv, 2023 Sep 15. PMID 37703372, Free PMC Article
  2. Posttranslational modification of microtubules by the MATCAP detyrosinase. Landskron L, et al. Science, 2022 May 20. PMID 35482892
  3. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Aregger M, et al. Nat Metab, 2020 Jun. PMID 32694731, Free PMC Article
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
  5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin-tyrosine carboxypeptidase IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
microtubule-associated tyrosine carboxypeptidase 1
Names
KIAA0895 like
microtubule-associated tyrosine carboxypeptidase
tubulin metallocarboxypeptidase 1
NP_001035805.1
NP_001356609.1
NP_001356610.1
NP_001356611.1
NP_001356613.1
NP_001356614.1
NP_001356615.1
NP_001356616.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040715.2 → NP_001035805.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

    See identical proteins and their annotated locations for NP_001035805.1

    Status: VALIDATED

    Source sequence(s)
    AC074143, BC007594, BC080183, BX460002
    Consensus CDS
    CCDS42177.1
    UniProtKB/Swiss-Prot
    A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
    Related
    ENSP00000456838.1, ENST00000563902.2
    Conserved Domains (1) summary
    cl06858
    Location:237 → 445
    DUF1704; Domain of unknown function (DUF1704)

  2. NM_001369680.1 → NP_001356609.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42177.1
    UniProtKB/Swiss-Prot
    A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
    Related
    ENSP00000290881.7, ENST00000290881.11
    Conserved Domains (1) summary
    cl06858
    Location:237 → 445
    DUF1704; Domain of unknown function (DUF1704)

  3. NM_001369681.1 → NP_001356610.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42177.1
    UniProtKB/Swiss-Prot
    A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
    Conserved Domains (1) summary
    cl06858
    Location:237 → 445
    DUF1704; Domain of unknown function (DUF1704)

  4. NM_001369682.1 → NP_001356611.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42177.1
    UniProtKB/Swiss-Prot
    A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
    Conserved Domains (1) summary
    cl06858
    Location:237 → 445
    DUF1704; Domain of unknown function (DUF1704)

  5. NM_001369684.1 → NP_001356613.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42177.1
    UniProtKB/Swiss-Prot
    A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
    Conserved Domains (1) summary
    cl06858
    Location:237 → 445
    DUF1704; Domain of unknown function (DUF1704)

  6. NM_001369685.1 → NP_001356614.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42177.1
    UniProtKB/Swiss-Prot
    A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
    Conserved Domains (1) summary
    cl06858
    Location:237 → 445
    DUF1704; Domain of unknown function (DUF1704)

  7. NM_001369686.1 → NP_001356615.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42177.1
    UniProtKB/Swiss-Prot
    A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
    Conserved Domains (1) summary
    cl06858
    Location:237 → 445
    DUF1704; Domain of unknown function (DUF1704)

  8. NM_001369687.1 → NP_001356616.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS92174.1
    Related
    ENSP00000457099.1, ENST00000561621.5
    Conserved Domains (1) summary
    cl06858
    Location:144 → 377
    DUF1704; Domain of unknown function (DUF1704)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67175599..67183963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    72969893..72978247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68EN5.1 GenPept UniProtKB/Swiss-Prot:Q68EN5

Gene LinkOut

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