OCM oncomodulin [Homo sapiens (human)] - Gene

Summary

Official Symbol: OCMprovided by HGNC
Official Full Name: oncomodulinprovided by HGNC
Primary source: HGNC:HGNC:8105
See related: Ensembl:ENSG00000122543 MIM:164795; AllianceGenome:HGNC:8105
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OM; OCM1; ONCM
Summary: Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors. [provided by RefSeq, Jul 2008]
Annotation information: Note: There are two oncomodulin-like loci on chromosome 7 (GeneIDs 4951 and 654231). The nomenclature for the p and q arm locations was modified to agree with reports (including PMID: 1559707) that place the OCM gene on the p arm. [18 Jun 2007]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7p22.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (5859718..5886363)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (5977469..6004117)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (5899349..5925994)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of oncomodulin in outer hair cells, leads to a progressive hearing loss in transgenic mice.
Title: Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice.
Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified.
Title: Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3.
Ocm plays a central role in inflammation-induced regeneration in the optic nerve.
Title: Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:481852

GDB:217597 (e-PCR)
- UniSTS:156231

NoName (e-PCR)
- UniSTS:490170

RH78909 (e-PCR)
- UniSTS:86730

RH40682 (e-PCR)
- UniSTS:92120

Clone Names

MGC97453, MGC97465, MGC97477, MGC142264, MGC142266

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: oncomodulin-1

Names: beta parvalbumin; hCG18255; parvalbumin beta

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097622.2 → NP_001091091.1 oncomodulin-1 isoform a

See identical proteins and their annotated locations for NP_001091091.1

Status: VALIDATED

Source sequence(s)

BC113704, CB045979, DB339645

Consensus CDS

CCDS43548.1

UniProtKB/Swiss-Prot

B9EJH7, P0CE72

Related

ENSP00000242104.5, ENST00000242104.6

Conserved Domains (1) summary

cd16255
Location:9 → 109

EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin
NM_001391990.1 → NP_001378919.1 oncomodulin-1 isoform a

Status: VALIDATED

Source sequence(s)

AC004983

Consensus CDS

CCDS43548.1

UniProtKB/Swiss-Prot

B9EJH7, P0CE72

Conserved Domains (1) summary

cd16255
Location:9 → 109

EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin
NM_001391991.1 → NP_001378920.1 oncomodulin-1 isoform b

Status: VALIDATED

Source sequence(s)

AC004983

Conserved Domains (2) summary

cd16251
Location:5 → 34

EFh_parvalbumin_like; EF-hand motif [structural motif]

cl25356
Location:1 → 71

EFh_parvalbumin_like; EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family