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OR2B8P olfactory receptor family 2 subfamily B member 8 pseudogene [ Homo sapiens (human) ]

Gene ID: 65944, updated on 23-Nov-2023

Summary

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Official Symbol
OR2B8Pprovided by HGNC
Official Full Name
olfactory receptor family 2 subfamily B member 8 pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:13968
See related
Ensembl:ENSG00000182477 AllianceGenome:HGNC:13968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2B8; OR6-10; dJ313I6.4; hs6M1-29P
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
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Genomic context

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See OR2B8P in Genome Data Viewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28053228..28054202, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27922854..27923828, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28021006..28021980, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily W member 2 pseudogene Neighboring gene olfactory receptor family 2 subfamily B member 7 pseudogene Neighboring gene olfactory receptor family 1 subfamily F member 12, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24342 Neighboring gene zinc finger protein 165

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative olfactory receptor 2B8
Names
Olfactory receptor 2B8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395874.1 → NP_001382803.1  putative olfactory receptor 2B8

    Status: VALIDATED

    Source sequence(s)
    AL121944, GU251070
    UniProtKB/TrEMBL
    A0A126GVB6
    Conserved Domains (1) summary
    cd15947
    Location:33 → 294
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_174096.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121944
    Related
    ENST00000432841.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    28053228..28054202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    27922854..27923828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_003194.3: Suppressed sequence

    Description
    NG_003194.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59922.1 GenPept UniProtKB/Swiss-Prot:P59922

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials