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Tmem176b transmembrane protein 176B [ Mus musculus (house mouse) ]

Gene ID: 65963, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem176bprovided by MGI
Official Full Name
transmembrane protein 176Bprovided by MGI
Primary source
MGI:MGI:1916348
See related
Ensembl:ENSMUSG00000029810 AllianceGenome:MGI:1916348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lr8; Clast1; 1810009M01Rik
Summary
Acts upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TMEM176B (transmembrane protein 176B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 289.3), adrenal adult (RPKM 166.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem176b in Genome Data Viewer
Location:
6 B2.3; 6 23.75 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48810745..48818363, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48833811..48845948, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30781 Neighboring gene STARR-positive B cell enhancer ABC_E10379 Neighboring gene septin 7 pseudogene Neighboring gene transmembrane protein 176A Neighboring gene predicted gene 44764 Neighboring gene predicted gene 7932

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Potential Diagnostic and Prognostic Biomarker TMEM176B and Its Relationship With Immune Infiltration in Skin Cutaneous Melanoma. Jiang L, et al. Front Cell Dev Biol, 2022. PMID 35399535, Free PMC Article
  2. Oncogenic Ras-mediated downregulation of Clast1/LR8 is involved in Ras-mediated neoplastic transformation and tumorigenesis in NIH3T3 cells. Ryu SH, et al. Cancer Sci, 2010 Sep. PMID 20550525, Free PMC Article
  3. Generation of a Double KO Mouse by Simultaneous Targeting of the Neighboring Genes Tmem176a and Tmem176b Using CRISPR/Cas9: Key Steps from Design to Genotyping. Lemoine A, et al. J Genet Genomics, 2016 May 20. PMID 27234594
  4. Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation. Segovia M, et al. Am J Transplant, 2014 May. PMID 24731243, Free PMC Article
  5. A novel factor, Tmem176b, induced by activin-like kinase 2 signal promotes the differentiation of myoblasts into osteoblasts. Yano M, et al. Exp Clin Endocrinol Diabetes, 2014 Jan. PMID 24085390

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells.
    Title: Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells.
  2. myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion.
    Title: Cry2 Is Critical for Circadian Regulation of Myogenic Differentiation by Bclaf1-Mediated mRNA Stabilization of Cyclin D1 and Tmem176b.
  3. Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function related to a colocalisation in close proximity to the Golgi apparatus.
    Title: RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.
  4. Tmem176b induces the differentiation of myoblasts into an osteoblast lineage.
    Title: A novel factor, Tmem176b, induced by activin-like kinase 2 signal promotes the differentiation of myoblasts into osteoblasts.
  5. data identify the downregulation of Clast1/LR8 as a potentially important mechanism by which oncogenic Ras-mediated neoplastic transformation occurs
    Title: Oncogenic Ras-mediated downregulation of Clast1/LR8 is involved in Ras-mediated neoplastic transformation and tumorigenesis in NIH3T3 cells.
  6. These data suggest that Tmem176B and Tmem176A associate to form multimers and restrain dendritic cell maturation.
    Title: Tmem176B and Tmem176A are associated with the immature state of dendritic cells.
  7. The Clast1 gene is ubiquitously expressed in various organs of adult mice and is required for development of cerebellar granule cells.
    Title: Role of Clast1 in development of cerebellar granule cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dendritic cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 176B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164207.1 → NP_001157679.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001157679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC115045, AK007408, BE457679, DV047496
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Related
    ENSMUSP00000131064.2, ENSMUST00000166247.8
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  2. NM_001164208.1 → NP_001157680.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001157680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC115045, AK007408, BE457679, BQ571258, DV047496
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  3. NM_001164209.2 → NP_001157681.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001157681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AK007408, BE457679, CX213755, CX223561, DV047496
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Related
    ENSMUSP00000098972.5, ENSMUST00000101429.11
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  4. NM_001286651.1 → NP_001273580.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001273580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AK007408, BE457679, CX213755, CX223561, DV047496
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  5. NM_001286652.1 → NP_001273581.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001273581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AK007408, BE457679, CX213755, CX223561, DV059241
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Related
    ENSMUSP00000144864.2, ENSMUST00000204073.3
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  6. NM_023056.4 → NP_075543.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_075543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AB031386, AC115045, BE457679
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Related
    ENSMUSP00000128705.2, ENSMUST00000164733.4
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

RNA

  1. NR_104575.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' terminal exon and lacks an exon in the 5' region, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK007408, BE457679, CX213755, CX223561, DV047496

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48810745..48818363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152260.1 → XP_036008153.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  2. XM_006506459.5 → XP_006506522.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506522.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  3. XM_030255531.2 → XP_030111391.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  4. XM_006506458.4 → XP_006506521.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506521.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  5. XM_006506457.5 → XP_006506520.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506520.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  6. XM_030255532.2 → XP_030111392.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Related
    ENSMUSP00000145395.2, ENSMUST00000203355.3
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  7. XM_030255534.2 → XP_030111394.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  8. XM_006506456.5 → XP_006506519.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506519.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  9. XM_017321710.3 → XP_017177199.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  10. XM_006506460.5 → XP_006506523.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506523.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  11. XM_030255533.2 → XP_030111393.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  12. XM_030255535.2 → XP_030111395.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1Q6.1 GenPept UniProtKB/Swiss-Prot:Q9R1Q6

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