U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eefsec eukaryotic elongation factor, selenocysteine-tRNA-specific [ Mus musculus (house mouse) ]

Gene ID: 65967, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Eefsecprovided by MGI
Official Full Name
eukaryotic elongation factor, selenocysteine-tRNA-specificprovided by MGI
Primary source
MGI:MGI:2137092
See related
Ensembl:ENSMUSG00000033216 AllianceGenome:MGI:2137092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sec; Selb; mSelB
Summary
Enables several functions, including GTP binding activity; GTPase activity; and nucleic acid binding activity. Acts upstream of or within selenocysteine incorporation. Located in mitochondrion. Part of ribonucleoprotein complex. Orthologous to human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 23.2), ovary adult (RPKM 18.3) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Eefsec in Genome Data Viewer
Location:
6 D1; 6 39.32 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88234318..88423489, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88257334..88446552, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene stem and progenitor enriched required for hematopoietic differentiation Neighboring gene Gata2R5 erythroid cis-regulatory module Neighboring gene GATA binding protein 2 Neighboring gene Gata2R6 erythroid cis-regulatory module Neighboring gene DnaJ heat shock protein family (Hsp40) member B8 Neighboring gene predicted gene, 57776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88415220-88415403 Neighboring gene predicted gene, 44264 Neighboring gene STARR-seq mESC enhancer starr_16584 Neighboring gene RuvB-like AAA ATPase 1 Neighboring gene predicted gene, 46965 Neighboring gene SEC61 translocon subunit alpha 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Selenocysteine-Specific Elongation Factor Contains Unique Sequences That Are Required for Both Nuclear Export and Selenocysteine Incorporation. Dubey A, et al. PLoS One, 2016. PMID 27802322, Free PMC Article
  2. The selenocysteine-specific elongation factor contains a novel and multi-functional domain. Gonzalez-Flores JN, et al. J Biol Chem, 2012 Nov 9. PMID 22992746, Free PMC Article
  3. Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation. Fagegaltier D, et al. EMBO J, 2000 Sep 1. PMID 10970870, Free PMC Article
  4. Supramolecular complexes mediate selenocysteine incorporation in vivo. Small-Howard A, et al. Mol Cell Biol, 2006 Mar. PMID 16508009, Free PMC Article
  5. Decoding apparatus for eukaryotic selenocysteine insertion. Tujebajeva RM, et al. EMBO Rep, 2000 Aug. PMID 11265756, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables selenocysteine insertion sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in selenocysteine incorporation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within selenocysteine incorporation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within selenocysteine incorporation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in selenocysteine incorporation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
selenocysteine-specific elongation factor
Names
MJ0495-like protein SelB
elongation factor sec

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411439.1 → NP_001398368.1  selenocysteine-specific elongation factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927
    UniProtKB/TrEMBL
    A0A0N4SUV6
    Related
    ENSMUSP00000144839.2, ENSMUST00000205179.3

  2. NM_001411440.1 → NP_001398369.1  selenocysteine-specific elongation factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  3. NM_001411441.1 → NP_001398370.1  selenocysteine-specific elongation factor isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  4. NM_001411442.1 → NP_001398371.1  selenocysteine-specific elongation factor isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  5. NM_001411443.1 → NP_001398372.1  selenocysteine-specific elongation factor isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  6. NM_001411444.1 → NP_001398373.1  selenocysteine-specific elongation factor isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  7. NM_001411445.1 → NP_001398374.1  selenocysteine-specific elongation factor isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  8. NM_001411446.1 → NP_001398375.1  selenocysteine-specific elongation factor isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC153694

  9. NM_001411447.1 → NP_001398376.1  selenocysteine-specific elongation factor isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927
    Related
    ENSMUSP00000145480.2, ENSMUST00000203213.3

  10. NM_001411448.1 → NP_001398377.1  selenocysteine-specific elongation factor isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC153694
    Related
    ENSMUSP00000144824.2, ENSMUST00000204459.3

  11. NM_001411449.1 → NP_001398378.1  selenocysteine-specific elongation factor isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC153694

  12. NM_001411450.1 → NP_001398379.1  selenocysteine-specific elongation factor isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC153694

  13. NM_001411451.1 → NP_001398380.1  selenocysteine-specific elongation factor isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC153694

  14. NM_023060.4 → NP_075547.1  selenocysteine-specific elongation factor isoform 1

    See identical proteins and their annotated locations for NP_075547.1

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927
    Consensus CDS
    CCDS20335.1
    UniProtKB/Swiss-Prot
    Q6GTZ5, Q9JHW4
    UniProtKB/TrEMBL
    Q3UGH6
    Related
    ENSMUSP00000131207.2, ENSMUST00000165242.4
    Conserved Domains (4) summary
    cd01889
    Location:8 → 197
    SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
    pfam00009
    Location:8 → 195
    GTP_EFTU; Elongation factor Tu GTP binding domain
    cd03696
    Location:210 → 292
    SelB_II; Domain II of elongation factor SelB
    cd04094
    Location:297 → 437
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB

RNA

  1. NR_149744.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  2. NR_177254.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  3. NR_177255.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  4. NR_177256.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  5. NR_177257.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  6. NR_177258.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  7. NR_177259.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  8. NR_177260.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  9. NR_177261.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  10. NR_177262.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  11. NR_177263.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  12. NR_177264.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

  13. NR_177265.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694

  14. NR_177266.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153694, AC153927

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    88234318..88423489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHW4.2 GenPept UniProtKB/Swiss-Prot:Q9JHW4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools