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Rogdi rogdi homolog [ Mus musculus (house mouse) ]

Gene ID: 66049, updated on 2-Nov-2024

Summary

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Official Symbol
Rogdiprovided by MGI
Official Full Name
rogdi homologprovided by MGI
Primary source
MGI:MGI:1913299
See related
Ensembl:ENSMUSG00000022540 AllianceGenome:MGI:1913299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lzf; 0610011C19Rik
Summary
Acts upstream of or within several processes, including enamel mineralization; locomotor rhythm; and pH reduction. Predicted to be located in nuclear envelope. Predicted to be part of RAVE complex. Predicted to be active in hippocampal mossy fiber to CA3 synapse and presynapse. Is expressed in several structures, including central nervous system; genitourinary system; nose; spinal ganglion; and tooth. Used to study Kohlschutter-Tonz syndrome. Human ortholog(s) of this gene implicated in Kohlschutter-Tonz syndrome. Orthologous to human ROGDI (rogdi atypical leucine zipper). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 83.8), kidney adult (RPKM 80.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rogdi in Genome Data Viewer
Location:
16 A1; 16 2.49 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4826593..4831438, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5008729..5013574, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene septin 12 Neighboring gene STARR-positive B cell enhancer ABC_E7426 Neighboring gene small integral membrane protein 22 Neighboring gene glyoxylate reductase 1 homolog (Arabidopsis) Neighboring gene STARR-positive B cell enhancer ABC_E1180 Neighboring gene ubinuclein 1 Neighboring gene predicted gene, 23483

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Rogdi knockout mouse is a model for Kohlschütter-Tönz syndrome. Jimenez-Armijo A, et al. Sci Rep, 2024 Jan 3. PMID 38172607, Free PMC Article
  2. Genetic approach and phenotype-based complementation screening for identification of stroma cell-derived proteins involved in cell proliferation. Tulin EE, et al. Exp Cell Res, 2002 Jan 1. PMID 11740862
  3. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article
  4. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Angrand PO, et al. Mol Cell Proteomics, 2006 Dec. PMID 16959763
  5. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Rogdi knockout mouse is a model for Kohlschutter-Tonz syndrome.
    Title: The Rogdi knockout mouse is a model for Kohlschütter-Tönz syndrome.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amelogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within circadian behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within enamel mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pH reduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RAVE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein rogdi homolog
Names
leucine zipper domain protein
leucine-zipper-containing LZF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133185.2 → NP_573448.2  protein rogdi homolog

    See identical proteins and their annotated locations for NP_573448.2

    Status: VALIDATED

    Source sequence(s)
    AK002523, BU604779, CD363552
    Consensus CDS
    CCDS79419.1
    UniProtKB/Swiss-Prot
    Q3TDK6, Q8BL37, Q922N4, Q923H8
    Related
    ENSMUSP00000144481.2, ENSMUST00000202281.4
    Conserved Domains (1) summary
    pfam10259
    Location:18 → 276
    Rogdi_lz; Rogdi leucine zipper containing protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4826593..4831438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160082.1 → XP_036015975.1  protein rogdi homolog isoform X1

    Conserved Domains (1) summary
    pfam10259
    Location:18 → 169
    Rogdi_lz; Rogdi leucine zipper containing protein

RNA

  1. XR_004939203.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TDK6.2 GenPept UniProtKB/Swiss-Prot:Q3TDK6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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