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Trappc2b trafficking protein particle complex 2B [ Mus musculus (house mouse) ]

Gene ID: 66050, updated on 28-Oct-2024

Summary

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Official Symbol
Trappc2bprovided by MGI
Official Full Name
trafficking protein particle complex 2Bprovided by MGI
Primary source
MGI:MGI:1913300
See related
Ensembl:ENSMUSG00000007777 AllianceGenome:MGI:1913300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610009B22Rik
Summary
Predicted to enable transcription corepressor binding activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. Predicted to be part of TRAPP complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including endocrine gland; gallbladder; genitourinary system; nervous system; and skeletal muscle tissue. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to human TRAPPC2 (trafficking protein particle complex subunit 2) and TRAPPC2B (trafficking protein particle complex subunit 2B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 9.5), CNS E14 (RPKM 9.3) and 28 other tissues See more
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Genomic context

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See Trappc2b in Genome Data Viewer
Location:
11 B1.3; 11 31.26 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51576207..51579929, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51685380..51689104, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3948 Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene NEDD4 binding protein 3 Neighboring gene predicted gene, 30058 Neighboring gene STARR-seq mESC enhancer starr_29425 Neighboring gene STARR-seq mESC enhancer starr_29426 Neighboring gene STARR-positive B cell enhancer ABC_E6981 Neighboring gene STARR-seq mESC enhancer starr_29427 Neighboring gene STARR-seq mESC enhancer starr_29428 Neighboring gene SEC24 homolog A, COPII coat complex component Neighboring gene predicted gene, 25291 Neighboring gene secretion associated Ras related GTPase 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPP complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Trafficking protein particle complex subunit 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417819.1 → NP_001404748.1  Trafficking protein particle complex subunit 2-like

    Status: VALIDATED

    Source sequence(s)
    AL645602
    UniProtKB/TrEMBL
    Q8R3W2

  2. NM_001417820.1 → NP_001404749.1  Trafficking protein particle complex subunit 2-like

    Status: VALIDATED

    Source sequence(s)
    AL645602
    UniProtKB/TrEMBL
    Q8R3W2
    Related
    ENSMUSP00000104726.2, ENSMUST00000109098.2

  3. NM_001417822.1 → NP_001404751.1  Trafficking protein particle complex subunit 2-like

    Status: VALIDATED

    Source sequence(s)
    AL645602
    UniProtKB/TrEMBL
    Q8R3W2

  4. NM_001417823.1 → NP_001404752.1  Trafficking protein particle complex subunit 2-like

    Status: VALIDATED

    Source sequence(s)
    AL645602
    UniProtKB/TrEMBL
    Q8R3W2

  5. NM_025319.3 → NP_079595.1  Trafficking protein particle complex subunit 2-like

    See identical proteins and their annotated locations for NP_079595.1

    Status: VALIDATED

    Source sequence(s)
    AL645602
    Consensus CDS
    CCDS36149.1
    UniProtKB/TrEMBL
    Q8R3W2
    Related
    ENSMUSP00000007921.3, ENSMUST00000007921.9
    Conserved Domains (1) summary
    cd14825
    Location:4 → 138
    TRAPPC2_sedlin; Trafficking protein particle complex subunit 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51576207..51579929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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