U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sf3b6 splicing factor 3B, subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 66055, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Sf3b6provided by MGI
Official Full Name
splicing factor 3B, subunit 6provided by MGI
Primary source
MGI:MGI:1913305
See related
Ensembl:ENSMUSG00000037361 AllianceGenome:MGI:1913305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sf3b14; 0610009D07Rik; 6030419K15Rik
Summary
Predicted to enable mRNA binding activity. Acts upstream of or within blastocyst formation and mRNA splicing, via spliceosome. Located in nucleus. Is expressed in central nervous system; early conceptus; secondary oocyte; and sensory organ. Orthologous to human SF3B6 (splicing factor 3b subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 55.9), bladder adult (RPKM 52.3) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sf3b6 in Genome Data Viewer
Location:
12 A1.1; 12 2.09 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4867608..4877659)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4817608..4827659)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C pseudogene Neighboring gene quinone oxidoreductase PIG3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8478 Neighboring gene FK506 binding protein 1b Neighboring gene STARR-positive B cell enhancer ABC_E4023 Neighboring gene WD repeat and coiled coil containing

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of four genes required for mammalian blastocyst formation. Maserati M, et al. Zygote, 2014 Aug. PMID 23211737
  2. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
  3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sf3b14 is required for the blastocyst formation.
    Title: Identification of four genes required for mammalian blastocyst formation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U12-type spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
splicing factor 3B subunit 6
Names
SF3B 14 kDa subunit
pre-mRNA branch site protein p14
splicing factor 3B, 14 kDa subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025323.2 → NP_079599.1  splicing factor 3B subunit 6

    See identical proteins and their annotated locations for NP_079599.1

    Status: PROVISIONAL

    Source sequence(s)
    BC019535
    Consensus CDS
    CCDS25791.1
    UniProtKB/Swiss-Prot
    P59708, Q3U9T9
    UniProtKB/TrEMBL
    A0A1W2P7L7
    Related
    ENSMUSP00000043662.8, ENSMUST00000046207.9
    Conserved Domains (1) summary
    cd12241
    Location:17 → 93
    RRM_SF3B14; RNA recognition motif (RRM) found in pre-mRNA branch site protein p14 (SF3B14) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    4867608..4877659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59708.1 GenPept UniProtKB/Swiss-Prot:P59708

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools