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Krtcap2 keratinocyte associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 66059, updated on 2-Nov-2024

Summary

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Official Symbol
Krtcap2provided by MGI
Official Full Name
keratinocyte associated protein 2provided by MGI
Primary source
MGI:MGI:1913309
See related
Ensembl:ENSMUSG00000042747 AllianceGenome:MGI:1913309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kcp2; 0610010I12Rik
Summary
Predicted to enable enzyme activator activity. Predicted to be involved in protein N-linked glycosylation. Part of oligosaccharyltransferase complex. Is expressed in several structures, including central nervous system and eye. Orthologous to human KRTCAP2 (keratinocyte associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 171.0), duodenum adult (RPKM 136.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Krtcap2 in Genome Data Viewer
Location:
3 F1; 3 39.03 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89153201..89157036)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89245904..89249729)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11198 Neighboring gene microRNA 92b Neighboring gene mucin 1, transmembrane Neighboring gene tripartite motif-containing 46 Neighboring gene STARR-positive B cell enhancer ABC_E4552 Neighboring gene dolichyl-phosphate mannosyltransferase polypeptide 3 Neighboring gene solute carrier family 50 (sugar transporter), member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DC2 and keratinocyte-associated protein 2 (KCP2), subunits of the oligosaccharyltransferase complex, are regulators of the gamma-secretase-directed processing of amyloid precursor protein (APP). Wilson CM, et al. J Biol Chem, 2011 Sep 9. PMID 21768116, Free PMC Article
  2. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Choquet H, et al. Nat Commun, 2021 Jun 14. PMID 34127677, Free PMC Article
  3. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. Shibatani T, et al. Biochemistry, 2005 Apr 26. PMID 15835887
  4. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. components of the oligosaccharyltransferase complex DC2 and KCP2 can interact with the gamma-secretase and affect the amyloid precursor protein processing pathway.
    Title: DC2 and keratinocyte-associated protein 2 (KCP2), subunits of the oligosaccharyltransferase complex, are regulators of the gamma-secretase-directed processing of amyloid precursor protein (APP).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
keratinocyte-associated protein 2
Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2
oligosaccharyl transferase subunit KCP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310625.1 → NP_001297554.1  keratinocyte-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001297554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AA032745, AC132327, AW495353
    Consensus CDS
    CCDS79949.1
    UniProtKB/TrEMBL
    A0A0A0MQN1
    Conserved Domains (1) summary
    pfam09775
    Location:1 → 109
    Keratin_assoc; Keratinocyte-associated protein 2

  2. NM_025327.3 → NP_079603.1  keratinocyte-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_079603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK002479, AW495353
    Consensus CDS
    CCDS50960.1
    UniProtKB/Swiss-Prot
    Q5RL79, Q9CQK5
    Related
    ENSMUSP00000043540.7, ENSMUST00000040888.12
    Conserved Domains (1) summary
    pfam09775
    Location:3 → 131
    Keratin_assoc; Keratinocyte-associated protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89153201..89157036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252748.2 → XP_030108608.1  keratinocyte-associated protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q5RL79, Q9CQK5
    Conserved Domains (1) summary
    pfam09775
    Location:3 → 131
    Keratin_assoc; Keratinocyte-associated protein 2

  2. XM_006501870.5 → XP_006501933.3  keratinocyte-associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam09775
    Location:86 → 214
    Keratin_assoc; Keratinocyte-associated protein 2

  3. XM_030252749.2 → XP_030108609.1  keratinocyte-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MQN1
    Related
    ENSMUSP00000130372.3, ENSMUST00000168900.3
    Conserved Domains (1) summary
    pfam09775
    Location:1 → 109
    Keratin_assoc; Keratinocyte-associated protein 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RL79.2 GenPept UniProtKB/Swiss-Prot:Q5RL79

Gene LinkOut

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