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Snupn snurportin 1 [ Mus musculus (house mouse) ]

Gene ID: 66069, updated on 2-Nov-2024

Summary

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Official Symbol
Snupnprovided by MGI
Official Full Name
snurportin 1provided by MGI
Primary source
MGI:MGI:1913319
See related
Ensembl:ENSMUSG00000055334 AllianceGenome:MGI:1913319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnut1; Snupn1; 0610031A09Rik
Summary
Predicted to enable RNA binding activity and nuclear import signal receptor activity. Predicted to be involved in RNA import into nucleus. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of NLS-dependent protein nuclear import complex. Is expressed in embryo. Orthologous to human SNUPN (snurportin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.0), testis adult (RPKM 5.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Snupn in Genome Data Viewer
Location:
9 B; 9 30.57 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56855158..56893545)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56949419..56986261)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1386 Neighboring gene predicted gene, 19936 Neighboring gene STARR-positive B cell enhancer ABC_E3831 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56798396-56798654 Neighboring gene IMP3, U3 small nucleolar ribonucleoprotein Neighboring gene STARR-seq mESC enhancer starr_24215 Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene predicted gene 10658 Neighboring gene STARR-positive B cell enhancer ABC_E5069 Neighboring gene STARR-seq mESC enhancer starr_24217 Neighboring gene RIKEN cDNA 2700012I20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9329 Neighboring gene STARR-positive B cell enhancer ABC_E711 Neighboring gene transcriptional regulator, SIN3A (yeast)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale multiplexed mosaic CRISPR perturbation in the whole organism. Liu B, et al. Cell, 2022 Aug 4. PMID 35870449
  2. Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. Huber J, et al. EMBO J, 1998 Jul 15. PMID 9670026, Free PMC Article
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA import into nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
snurportin-1
Names
RNA, U transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178374.4 → NP_848461.1  snurportin-1

    See identical proteins and their annotated locations for NP_848461.1

    Status: VALIDATED

    Source sequence(s)
    AC126257, AC132406
    Consensus CDS
    CCDS23214.1
    UniProtKB/Swiss-Prot
    Q80W37
    Related
    ENSMUSP00000067200.5, ENSMUST00000068856.5
    Conserved Domains (2) summary
    cd09232
    Location:98 → 282
    Snurportin-1_C; C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1
    pfam11538
    Location:25 → 64
    Snurportin1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56855158..56893545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511336.3 → XP_006511399.1  snurportin-1 isoform X2

    Conserved Domains (1) summary
    cd09232
    Location:26 → 210
    Snurportin-1_C; C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1

  2. XM_011242784.4 → XP_011241086.1  snurportin-1 isoform X1

    See identical proteins and their annotated locations for XP_011241086.1

    UniProtKB/Swiss-Prot
    Q80W37
    Conserved Domains (2) summary
    cd09232
    Location:98 → 282
    Snurportin-1_C; C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1
    pfam11538
    Location:25 → 64
    Snurportin1

  3. XM_030244488.1 → XP_030100348.1  snurportin-1 isoform X3

    Conserved Domains (1) summary
    cd09232
    Location:11 → 131
    Snurportin-1_C; C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1

RNA

  1. XR_003947964.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80W37.1 GenPept UniProtKB/Swiss-Prot:Q80W37

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