Ppih peptidyl prolyl isomerase H [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppihprovided by MGI
Official Full Name: peptidyl prolyl isomerase Hprovided by MGI
Primary source: MGI:MGI:106499
See related: Ensembl:ENSMUSG00000060288 AllianceGenome:MGI:106499
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CYPH; CYP-20; D4Wsu43e; 1100001J08Rik; 2010111B15Rik; 4833408F11Rik
Summary: Predicted to enable cyclosporin A binding activity; peptidyl-prolyl cis-trans isomerase activity; and ribonucleoprotein complex binding activity. Predicted to be involved in positive regulation of viral genome replication; protein folding; and protein peptidyl-prolyl isomerization. Predicted to be located in nuclear speck. Predicted to be part of U4/U6 snRNP and U4/U6 x U5 tri-snRNP complex. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including central nervous system; extraembryonic component; and retina. Orthologous to human PPIH (peptidylprolyl isomerase H). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in CNS E11.5 (RPKM 13.0), liver E14 (RPKM 10.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4 55.34 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (119157207..119177720, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (119300010..119320523, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI464484 (e-PCR)
- UniSTS:159276

RH125703 (e-PCR)
- UniSTS:142501

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclosporin A binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info
involved_in protein peptidyl-prolyl isomerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U4/U6 snRNP	ISO Inferred from Sequence Orthology more info
part_of U4/U6 x U5 tri-snRNP complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase H

Names: PPIase H; cyclophilin H; rotamase H

NP_001103599.1

EC 5.2.1.8

NP_001103600.1

EC 5.2.1.8

NP_082953.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110129.1 → NP_001103599.1 peptidyl-prolyl cis-trans isomerase H isoform 1

See identical proteins and their annotated locations for NP_001103599.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has a different 3' terminal non-coding exon compared to transcript variant 1. Transcript variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK136330, AK164299, CJ071503

Consensus CDS

CCDS18580.1

UniProtKB/TrEMBL

Q3UWH9, Q4G0C5

Related

ENSMUSP00000101928.3, ENSMUST00000106321.9

Conserved Domains (1) summary

cl00197
Location:8 → 177

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
NM_001110130.1 → NP_001103600.1 peptidyl-prolyl cis-trans isomerase H isoform 2

See identical proteins and their annotated locations for NP_001103600.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has a different 3' terminal exon compared to transcript variant 1, resulting in a longer isoform (2) with a different C-terminus compared to isoform 1.

Source sequence(s)

AK008394, BY708305, CJ071503

Consensus CDS

CCDS51288.1

UniProtKB/Swiss-Prot

Q9CQU7, Q9D868

UniProtKB/TrEMBL

Q3UWH9, Q3UY37

Related

ENSMUSP00000101924.2, ENSMUST00000106317.2

Conserved Domains (1) summary

cd01926
Location:11 → 155

cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
NM_028677.4 → NP_082953.1 peptidyl-prolyl cis-trans isomerase H isoform 1

See identical proteins and their annotated locations for NP_082953.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the most predominant transcript. Transcript variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK003179, BC050116, CJ071503

Consensus CDS

CCDS18580.1

UniProtKB/TrEMBL

Q3UWH9, Q4G0C5

Related

ENSMUSP00000101925.2, ENSMUST00000106318.8

Conserved Domains (1) summary

cl00197
Location:8 → 177

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...