Mtarc1 mitochondrial amidoxime reducing component 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtarc1provided by MGI
Official Full Name: mitochondrial amidoxime reducing component 1provided by MGI
Primary source: MGI:MGI:1913362
See related: Ensembl:ENSMUSG00000026621 AllianceGenome:MGI:1913362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Marc1; Mosc1; 1300013F15Rik
Summary: Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Orthologous to human MTARC1 (mitochondrial amidoxime reducing component 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in liver adult (RPKM 141.5), liver E18 (RPKM 31.5) and 4 other tissues See more
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Genomic context

Location:: 1 H5; 1 89.07 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (184518964..184543622, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (184786767..184811743, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Liver-specific mitochondrial amidoxime-reducing component 1 (Mtarc1) knockdown protects the liver from diet-induced MASH in multiple mouse models.
Title: Liver-specific mitochondrial amidoxime-reducing component 1 (Mtarc1) knockdown protects the liver from diet-induced MASH in multiple mouse models.
mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes.
Title: mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes.
Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse.
Title: Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse.
Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1.
Title: Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molybdenum ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables molybdenum ion binding	ISO Inferred from Sequence Orthology more info
enables molybdenum ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables molybdopterin cofactor binding	IBA Inferred from Biological aspect of Ancestor more info
enables molybdopterin cofactor binding	ISO Inferred from Sequence Orthology more info
enables molybdopterin cofactor binding	ISS Inferred from Sequence or Structural Similarity more info
enables nitrate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nitrate reductase activity	IEA Inferred from Electronic Annotation more info
enables nitrate reductase activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase (NO-forming) activity	IEA Inferred from Electronic Annotation more info
contributes_to nitrite reductase (NO-forming) activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on other nitrogenous compounds as donors	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of nitrogen compound	IEA Inferred from Electronic Annotation more info
involved_in cellular detoxification of nitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in nitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nitrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nitrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of nitric-oxide synthase complex	IEA Inferred from Electronic Annotation more info
part_of nitric-oxide synthase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial amidoxime-reducing component 1

Names: MOCO sulphurase C-terminal domain containing 1; MOSC domain-containing protein 1, mitochondrial; moco sulfurase C-terminal domain-containing protein 1; molybdenum cofactor sulfurase C-terminal domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290273.1 → NP_001277202.1 mitochondrial amidoxime-reducing component 1

See identical proteins and their annotated locations for NP_001277202.1

Status: VALIDATED

Source sequence(s)

AC131992, AC164539, AI480973, AK004989

Consensus CDS

CCDS69987.1

UniProtKB/Swiss-Prot

Q8R2L6, Q9CW42

Related

ENSMUSP00000035804.7, ENSMUST00000048462.13

Conserved Domains (3) summary

COG3217
Location:60 → 338

YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]

pfam03473
Location:207 → 336

MOSC; MOSC domain

pfam03476
Location:58 → 179

MOSC_N; MOSC N-terminal beta barrel domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

184518964..184543622 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497192.5 → XP_006497255.1 mitochondrial amidoxime-reducing component 1 isoform X1

Conserved Domains (2) summary

pfam03476
Location:58 → 179

MOSC_N; MOSC N-terminal beta barrel domain

pfam03473
Location:207 → 248

MOSC; MOSC domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001081361.1: Suppressed sequence

Description

NM_001081361.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.