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Elof1 ELF1 homolog, elongation factor 1 [ Mus musculus (house mouse) ]

Gene ID: 66126, updated on 2-Nov-2024

Summary

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Official Symbol
Elof1provided by MGI
Official Full Name
ELF1 homolog, elongation factor 1provided by MGI
Primary source
MGI:MGI:1913376
See related
Ensembl:ENSMUSG00000013822 AllianceGenome:MGI:1913376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110011K10Rik
Summary
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system. Orthologous to human ELOF1 (elongation factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 245.4), ovary adult (RPKM 51.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Elof1 in Genome Data Viewer
Location:
9 A3; 9 8.34 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (22024282..22028491, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22112986..22117195, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6581 Neighboring gene calponin 1 Neighboring gene microRNA 7084 Neighboring gene STARR-positive B cell enhancer ABC_E2285 Neighboring gene STARR-positive B cell enhancer ABC_E11403 Neighboring gene acid phosphatase 5, tartrate resistant Neighboring gene predicted gene, 39306

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The elongation factor Elof1 is required for mammalian gastrulation. Tellier AP, et al. PLoS One, 2019. PMID 31276560, Free PMC Article
  2. Discovery and validation of genes driving drug-intake and related behavioral traits in mice. Roy TA, et al. Genes Brain Behav, 2024 Jan 2. PMID 38164795, Free PMC Article
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription elongation factor 1 homolog
Names
elongation factor 1 homolog (ELF1, S. cerevisiae)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357309.1 → NP_001344238.1  transcription elongation factor 1 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    AC163623, BU583434
    Consensus CDS
    CCDS40559.1
    UniProtKB/Swiss-Prot
    P60003
    UniProtKB/TrEMBL
    Q545S6
    Related
    ENSMUSP00000150169.2, ENSMUST00000213233.2
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

  2. NM_001357310.1 → NP_001344239.1  transcription elongation factor 1 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    AC163623, DV649291
    Consensus CDS
    CCDS40559.1
    UniProtKB/Swiss-Prot
    P60003
    UniProtKB/TrEMBL
    Q545S6
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

  3. NM_001357311.1 → NP_001344240.1  transcription elongation factor 1 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    AC163623, AK003614
    Consensus CDS
    CCDS40559.1
    UniProtKB/Swiss-Prot
    P60003
    UniProtKB/TrEMBL
    Q545S6
    Related
    ENSMUSP00000013966.7, ENSMUST00000013966.8
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

  4. NM_001357312.1 → NP_001344241.1  transcription elongation factor 1 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    AC163623
    Consensus CDS
    CCDS40559.1
    UniProtKB/Swiss-Prot
    P60003
    UniProtKB/TrEMBL
    Q545S6
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

  5. NM_001357313.1 → NP_001344242.1  transcription elongation factor 1 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    AC163623
    Consensus CDS
    CCDS40559.1
    UniProtKB/Swiss-Prot
    P60003
    UniProtKB/TrEMBL
    Q545S6
    Related
    ENSMUSP00000150536.2, ENSMUST00000214394.2
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

  6. NM_001357314.1 → NP_001344243.1  transcription elongation factor 1 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    AC163623
    Consensus CDS
    CCDS40559.1
    UniProtKB/Swiss-Prot
    P60003
    UniProtKB/TrEMBL
    Q545S6
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

  7. NM_170777.4 → NP_740747.1  transcription elongation factor 1 homolog

    See identical proteins and their annotated locations for NP_740747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All seven variants encode the same protein.
    Source sequence(s)
    AC163623
    Consensus CDS
    CCDS40559.1
    UniProtKB/Swiss-Prot
    P60003
    UniProtKB/TrEMBL
    Q545S6
    Related
    ENSMUSP00000128173.2, ENSMUST00000166335.2
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    22024282..22028491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60003.1 GenPept UniProtKB/Swiss-Prot:P60003

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