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Tmem14c transmembrane protein 14C [ Mus musculus (house mouse) ]

Gene ID: 66154, updated on 28-Oct-2024

Summary

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Official Symbol
Tmem14cprovided by MGI
Official Full Name
transmembrane protein 14Cprovided by MGI
Primary source
MGI:MGI:1913404
See related
Ensembl:ENSMUSG00000021361 AllianceGenome:MGI:1913404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HSPC194; 1110021D01Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including erythrocyte differentiation; mitochondrial transport; and regulation of heme biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; hemolymphoid system; salivary gland primordium; sensory organ; and skeletal muscle. Orthologous to several human genes including TMEM14C (transmembrane protein 14C). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 150.0), liver E14.5 (RPKM 146.6) and 27 other tissues See more
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Genomic context

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See Tmem14c in Genome Data Viewer
Location:
13 A3.3; 13 20.25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41169726..41176058)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41016250..41022582)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene glucosaminyl (N-acetyl) transferase 2 (I blood group) Neighboring gene predicted gene, 31683 Neighboring gene STARR-seq mESC enhancer starr_34294 Neighboring gene RIKEN cDNA A730081D07 gene Neighboring gene STARR-positive B cell enhancer ABC_E11542 Neighboring gene STARR-positive B cell enhancer ABC_E9874 Neighboring gene PAK1 interacting protein 1 Neighboring gene male germ cell-associated kinase Neighboring gene glial cells missing homolog 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM14C is required for erythroid mitochondrial heme metabolism. Yien YY, et al. J Clin Invest, 2014 Oct. PMID 25157825, Free PMC Article
  2. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Nilsson R, et al. Cell Metab, 2009 Aug. PMID 19656490, Free PMC Article
  3. Identification of the Mitochondrial Heme Metabolism Complex. Medlock AE, et al. PLoS One, 2015. PMID 26287972, Free PMC Article
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM14C facilitates the import of protoporphyrinogen IX into the mitochondrial matrix for heme synthesis and subsequent hemoglobin production
    Title: TMEM14C is required for erythroid mitochondrial heme metabolism.
  2. Required for functional heme biosynthesis in erythroid cells.
    Title: Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitochondrial transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nitrogen compound transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 14C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360770.1 → NP_001347699.1  transmembrane protein 14C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133496
    UniProtKB/TrEMBL
    Q8C297
    Conserved Domains (1) summary
    pfam03647
    Location:5 → 94
    Tmemb_14; Transmembrane proteins 14C

  2. NM_025387.3 → NP_079663.1  transmembrane protein 14C isoform 1

    See identical proteins and their annotated locations for NP_079663.1

    Status: VALIDATED

    Source sequence(s)
    AK010609, BY785978, CO039120
    Consensus CDS
    CCDS26470.1
    UniProtKB/Swiss-Prot
    Q543H6, Q9CQN6, Q9D849
    Related
    ENSMUSP00000021790.6, ENSMUST00000021790.7
    Conserved Domains (1) summary
    pfam03647
    Location:13 → 102
    Tmemb_14; Transmembrane proteins 14C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    41169726..41176058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516938.3 → XP_006517001.1  transmembrane protein 14C isoform X1

    See identical proteins and their annotated locations for XP_006517001.1

    UniProtKB/TrEMBL
    Q8C297
    Conserved Domains (1) summary
    pfam03647
    Location:5 → 94
    Tmemb_14; Transmembrane proteins 14C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQN6.1 GenPept UniProtKB/Swiss-Prot:Q9CQN6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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