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Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) [ Mus musculus (house mouse) ]

Gene ID: 66168, updated on 2-Nov-2024

Summary

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Official Symbol
Grinaprovided by MGI
Official Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)provided by MGI
Primary source
MGI:MGI:1913418
See related
Ensembl:ENSMUSG00000022564 AllianceGenome:MGI:1913418
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lag; Tmbim3; 1110025J15Rik
Summary
Enables transmembrane transporter binding activity. Acts upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in cerebral cortex; genitourinary system; and heart valve. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 447.4), kidney adult (RPKM 386.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Grina in Genome Data Viewer
Location:
15 D3; 15 35.59 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76130917..76134109)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76246717..76249909)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene plectin Neighboring gene microRNA 1942 Neighboring gene poly (ADP-ribose) polymerase family, member 10 Neighboring gene microRNA 6953 Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene myocardial infraction associated transcript 2 Neighboring gene microRNA 3079

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia. Habib P, et al. Int J Mol Sci, 2019 Oct 31. PMID 31683519, Free PMC Article
  2. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Nielsen JA, et al. Mol Cell Biochem, 2011 Nov. PMID 21614515
  3. EPO regulates neuroprotective Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) family members GRINA and FAIM2 after cerebral ischemia-reperfusion injury. Habib P, et al. Exp Neurol, 2019 Oct. PMID 31211943
  4. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Rojas-Rivera D, et al. Cell Death Differ, 2012 Jun. PMID 22240901, Free PMC Article
  5. Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex. Tachikawa K, et al. Neurosci Res, 2008 Feb. PMID 18055048

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRINA/TMBIM3 plays a crucial role in post-ischemic unfolded protein response (UPR).
    Title: EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia.
  2. In this study, the authors show that TMBIM3 is expressed in the brain including high levels in the hippocampus.
    Title: Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein lifeguard 1
Names
NMDA receptor glutamate-binding subunit
glutamate [NMDA] receptor-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023168.3 → NP_075657.1  protein lifeguard 1

    See identical proteins and their annotated locations for NP_075657.1

    Status: PROVISIONAL

    Source sequence(s)
    AC110211
    Consensus CDS
    CCDS27563.1
    UniProtKB/Swiss-Prot
    Q8CI25, Q9ESF4
    Related
    ENSMUSP00000023225.7, ENSMUST00000023225.8
    Conserved Domains (2) summary
    cd10428
    Location:128 → 341
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    pfam15240
    Location:10 → 114
    Pro-rich; Proline-rich

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76130917..76134109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248690.1 → XP_030104550.1  protein lifeguard 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8CI25, Q9ESF4
    Conserved Domains (2) summary
    cd10428
    Location:128 → 341
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    pfam15240
    Location:10 → 114
    Pro-rich; Proline-rich

  2. XM_006521250.4 → XP_006521313.1  protein lifeguard 1 isoform X1

    See identical proteins and their annotated locations for XP_006521313.1

    UniProtKB/Swiss-Prot
    Q8CI25, Q9ESF4
    Conserved Domains (2) summary
    cd10428
    Location:128 → 341
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    pfam15240
    Location:10 → 114
    Pro-rich; Proline-rich

  3. XM_006521251.4 → XP_006521314.1  protein lifeguard 1 isoform X1

    See identical proteins and their annotated locations for XP_006521314.1

    UniProtKB/Swiss-Prot
    Q8CI25, Q9ESF4
    Conserved Domains (2) summary
    cd10428
    Location:128 → 341
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    pfam15240
    Location:10 → 114
    Pro-rich; Proline-rich

  4. XM_011245709.3 → XP_011244011.1  protein lifeguard 1 isoform X1

    See identical proteins and their annotated locations for XP_011244011.1

    UniProtKB/Swiss-Prot
    Q8CI25, Q9ESF4
    Conserved Domains (2) summary
    cd10428
    Location:128 → 341
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    pfam15240
    Location:10 → 114
    Pro-rich; Proline-rich

  5. XM_006521249.4 → XP_006521312.1  protein lifeguard 1 isoform X1

    See identical proteins and their annotated locations for XP_006521312.1

    UniProtKB/Swiss-Prot
    Q8CI25, Q9ESF4
    Conserved Domains (2) summary
    cd10428
    Location:128 → 341
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    pfam15240
    Location:10 → 114
    Pro-rich; Proline-rich
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESF4.1 GenPept UniProtKB/Swiss-Prot:Q9ESF4

Gene LinkOut

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