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Cd302 CD302 antigen [ Mus musculus (house mouse) ]

Gene ID: 66205, updated on 2-Nov-2024

Summary

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Official Symbol
Cd302provided by MGI
Official Full Name
CD302 antigenprovided by MGI
Primary source
MGI:MGI:1913455
See related
Ensembl:ENSMUSG00000060703 AllianceGenome:MGI:1913455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110055L24Rik
Summary
Predicted to enable signaling receptor activity. Predicted to act upstream of or within phagocytosis. Predicted to be located in cell cortex and filopodium. Predicted to be active in external side of plasma membrane. Is expressed in ear; embryo; and forelimb bud. Orthologous to human CD302 (CD302 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver adult (RPKM 77.5), liver E18 (RPKM 52.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Cd302 in Genome Data Viewer
Location:
2 C1.1; 2 34.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (60082337..60114828, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (60251993..60284484, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene STARR-seq mESC enhancer starr_04605 Neighboring gene lactate dehydrogenase A, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5922 Neighboring gene STARR-seq mESC enhancer starr_04606 Neighboring gene STARR-seq mESC enhancer starr_04607 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene STARR-seq mESC enhancer starr_04608 Neighboring gene ribosomal protein L10A, pseudogene 4 Neighboring gene lymphocyte antigen 75 Neighboring gene predicted gene 13571 Neighboring gene STARR-seq mESC enhancer starr_04613 Neighboring gene predicted gene 13580

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration. Lo TH, et al. J Immunol, 2016 Aug 1. PMID 27316686
  2. AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells. Yasuda S, et al. Biochem J, 2011 Jul 15. PMID 21554246
  3. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. Kato M, et al. J Immunol, 2007 Nov 1. PMID 17947679
  4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These studies confirm a functional role for CD302 in myeloid dendritic cells migration.
    Title: Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.
  2. hDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration
    Title: The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phagocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microvillus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD302 antigen
Names
C-type lectin domain family 13 member A
type I transmembrane C-type lectin receptor DCL-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290660.1 → NP_001277589.1  CD302 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_001277589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA222439, AI116405, AK002812
    Consensus CDS
    CCDS71058.1
    UniProtKB/Swiss-Prot
    A2AW84, A2AW85, Q78KD8, Q9D0X7, Q9DCG2
    Related
    ENSMUSP00000074188.5, ENSMUST00000074606.11
    Conserved Domains (1) summary
    smart00034
    Location:22 → 151
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

  2. NM_025422.4 → NP_079698.2  CD302 antigen isoform b precursor

    See identical proteins and their annotated locations for NP_079698.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AA222439, AI116405, AK004267
    Consensus CDS
    CCDS16058.1
    UniProtKB/Swiss-Prot
    Q9DCG2
    Related
    ENSMUSP00000028356.9, ENSMUST00000028356.9
    Conserved Domains (1) summary
    smart00034
    Location:22 → 151
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    60082337..60114828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCG2.2 GenPept UniProtKB/Swiss-Prot:Q9DCG2

Gene LinkOut

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