Llph LLP homolog, long-term synaptic facilitation (Aplysia) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Llphprovided by MGI
Official Full Name: LLP homolog, long-term synaptic facilitation (Aplysia)provided by MGI
Primary source: MGI:MGI:1913475
See related: Ensembl:ENSMUSG00000020224 AllianceGenome:MGI:1913475
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1190005P17Rik
Summary: Enables basal RNA polymerase II transcription machinery binding activity. Involved in dendrite extension and positive regulation of dendritic spine development. Located in nucleolus. Orthologous to human LLPH (LLP homolog, long-term synaptic facilitation factor). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in liver E14 (RPKM 29.1), CNS E11.5 (RPKM 23.5) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 67.94 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (120062967..120067976)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (120227048..120232071)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the characteristics and roles of previously unknown cell-permeable protein mLLP in modulating neural development.
Title: A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables basal RNA polymerase II transcription machinery binding	IBA Inferred from Biological aspect of Ancestor more info
enables basal RNA polymerase II transcription machinery binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dendrite extension	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein LLP homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.