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Dimt1 DIM1 rRNA methyltransferase and ribosome maturation factor [ Mus musculus (house mouse) ]

Gene ID: 66254, updated on 28-Oct-2024

Summary

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Official Symbol
Dimt1provided by MGI
Official Full Name
DIM1 rRNA methyltransferase and ribosome maturation factorprovided by MGI
Primary source
MGI:MGI:1913504
See related
Ensembl:ENSMUSG00000021692 AllianceGenome:MGI:1913504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dimt1l; 1500031M22Rik
Summary
Predicted to enable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity. Predicted to be involved in positive regulation of rRNA processing; rRNA methylation; and ribosomal small subunit biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in telencephalon ventricular layer. Orthologous to human DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E18 (RPKM 7.5), limb E14.5 (RPKM 6.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Dimt1 in Genome Data Viewer
Location:
13 D2.1; 13 58.06 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (107083637..107097833)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (106947071..106961325)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Ipo11-lrrc70 readthrough Neighboring gene importin 11 Neighboring gene STARR-seq mESC enhancer starr_35565 Neighboring gene leucine rich repeat containing 70 Neighboring gene STARR-seq mESC enhancer starr_35568 Neighboring gene STARR-seq mESC enhancer starr_35569 Neighboring gene STARR-seq mESC enhancer starr_35570 Neighboring gene predicted gene, 57603 Neighboring gene STARR-positive B cell enhancer ABC_E1165 Neighboring gene STARR-positive B cell enhancer ABC_E7276 Neighboring gene kinesin family member 2A Neighboring gene RIKEN cDNA 3830408C21 gene Neighboring gene STARR-positive B cell enhancer ABC_E11558 Neighboring gene STARR-seq mESC enhancer starr_35572 Neighboring gene STARR-seq mESC enhancer starr_35573 Neighboring gene STARR-positive B cell enhancer ABC_E5414 Neighboring gene predicted gene, 31715

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  2. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  3. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dimethyladenosine transferase; probable dimethyladenosine transferase
Names
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
18S rRNA dimethylase
DIM1 dimethyladenosine transferase 1 homolog
DIM1 dimethyladenosine transferase 1-like
S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
probable 18S rRNA dimethylase
probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
NP_079723.1
XP_036013995.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025447.4 → NP_079723.1  dimethyladenosine transferase

    See identical proteins and their annotated locations for NP_079723.1

    Status: VALIDATED

    Source sequence(s)
    AK011544, AK078186, BF608861
    Consensus CDS
    CCDS26758.1
    UniProtKB/Swiss-Prot
    Q3TTJ5, Q8BVH8, Q9D0D4
    UniProtKB/TrEMBL
    Q3UK38
    Related
    ENSMUSP00000022203.9, ENSMUST00000022203.10
    Conserved Domains (1) summary
    PTZ00338
    Location:27 → 312
    PTZ00338; dimethyladenosine transferase-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    107083637..107097833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158102.1 → XP_036013995.1  probable dimethyladenosine transferase isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:1 → 159
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0D4.1 GenPept UniProtKB/Swiss-Prot:Q9D0D4

Gene LinkOut

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