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Pigyl phosphatidylinositol glycan anchor biosynthesis, class Y-like [ Mus musculus (house mouse) ]

Gene ID: 66268, updated on 2-Nov-2024

Summary

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Official Symbol
Pigylprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Y-likeprovided by MGI
Primary source
MGI:MGI:1913518
See related
Ensembl:ENSMUSG00000010607 AllianceGenome:MGI:1913518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pigy; PIG-Y; 1810008A14Rik
Summary
This gene encodes a homolog of a human protein that functions in glycosylphosphatidylinositol biosynthesis. The human protein is expressed from an unusual locus that encodes two distinct proteins in upstream and downstream CDSes; however, in mouse these two proteins are expressed from distinct loci. The product of this locus is highly similar to the protein expressed from the human downstream CDS. A separate mouse locus on chromosome 6 is orthologous to the human locus and encodes a protein similar to the human protein expressed from the upstream CDS. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 30.9), ovary adult (RPKM 27.8) and 28 other tissues See more
Orthologs
all
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Genomic context

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See Pigyl in Genome Data Viewer
Location:
9 A3; 9 8.46 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (22068142..22069651)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22156846..22158355)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene acid phosphatase 5, tartrate resistant Neighboring gene predicted gene, 39306 Neighboring gene STARR-positive B cell enhancer ABC_E1380 Neighboring gene STARR-seq mESC enhancer starr_23536 Neighboring gene zinc finger protein 867 pseudogene Neighboring gene ribosomal protein L15, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Murakami Y, et al. Mol Biol Cell, 2005 Nov. PMID 16162815, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
Names
phosphatidylinositol-glycan biosynthesis class Y protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082532.1 → NP_001076001.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

    See identical proteins and their annotated locations for NP_001076001.1

    Status: REVIEWED

    Source sequence(s)
    AI414555, AK007367, BU558514
    Consensus CDS
    CCDS52742.1
    UniProtKB/Swiss-Prot
    P0C1P0
    Related
    ENSMUSP00000116929.2, ENSMUST00000123680.2
    Conserved Domains (1) summary
    pfam15159
    Location:5 → 70
    PIG-Y; Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    22068142..22069651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025457.1: Suppressed sequence

    Description
    NM_025457.1: This RefSeq was permanently suppressed because currently there is limited support for the transcript but not the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C1P0.1 GenPept UniProtKB/Swiss-Prot:P0C1P0

Gene LinkOut

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