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Gkn1 gastrokine 1 [ Mus musculus (house mouse) ]

Gene ID: 66283, updated on 2-Nov-2024

Summary

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Official Symbol
Gkn1provided by MGI
Official Full Name
gastrokine 1provided by MGI
Primary source
MGI:MGI:1913533
See related
Ensembl:ENSMUSG00000030050 AllianceGenome:MGI:1913533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fov; AMP-18; BRICD1; 2200002K21Rik
Summary
Enables growth factor activity. Acts upstream of or within positive regulation of cell population proliferation. Located in secretory granule. Is expressed in several structures, including aorta; gut; quadriceps femoris muscle; reproductive system; and sciatic nerve. Orthologous to human GKN1 (gastrokine 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward stomach adult (RPKM 9380.5) See more
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Genomic context

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See Gkn1 in Genome Data Viewer
Location:
6 D1; 6 37.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87322635..87327897, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87345653..87350915, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene anthrax toxin receptor 1 Neighboring gene predicted gene, 34170 Neighboring gene predicted gene, 34090 Neighboring gene gastrokine 2 Neighboring gene gastrokine 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gastrokine-1, an anti-amyloidogenic protein secreted by the stomach, regulates diet-induced obesity. Overstreet AC, et al. Sci Rep, 2021 May 4. PMID 33947892, Free PMC Article
  2. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. Martin TE, et al. Am J Physiol Gastrointest Liver Physiol, 2003 Aug. PMID 12851218
  3. De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer. Steiner S, et al. Oncogene, 2022 Mar. PMID 35082384, Free PMC Article
  4. AMP-18 Targets p21 to Maintain Epithelial Homeostasis. Chen P, et al. PLoS One, 2015. PMID 25919700, Free PMC Article
  5. Quantitative genetics of age-related retinal degeneration: a second F1 intercross between the A/J and C57BL/6 strains. Danciger M, et al. Mol Vis, 2007 Jan 25. PMID 17277741, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gastrokine-1
Names
18 kDa antrum mucosa protein
foveolin
protein CA11 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025466.1 → NP_079742.1  gastrokine-1 precursor

    See identical proteins and their annotated locations for NP_079742.1

    Status: VALIDATED

    Source sequence(s)
    AK008622
    Consensus CDS
    CCDS20319.1
    UniProtKB/Swiss-Prot
    Q9CR36, Q9CTZ5, Q9D7K7
    UniProtKB/TrEMBL
    Q53YU8
    Related
    ENSMUSP00000032129.2, ENSMUST00000032129.3
    Conserved Domains (1) summary
    smart01039
    Location:54 → 148
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    87322635..87327897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR36.3 GenPept UniProtKB/Swiss-Prot:Q9CR36

Gene LinkOut

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