U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dus2 dihydrouridine synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 66369, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Dus2provided by MGI
Official Full Name
dihydrouridine synthase 2provided by MGI
Primary source
MGI:MGI:1913619
See related
Ensembl:ENSMUSG00000031901 AllianceGenome:MGI:1913619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dus2l; 2310016K04Rik
Summary
Predicted to enable several functions, including double-stranded RNA binding activity; nucleotide binding activity; and tRNA-dihydrouridine20 synthase activity. Predicted to be involved in antiviral innate immune response and tRNA dihydrouridine synthesis. Located in mitochondrion. Is expressed in central nervous system and sensory organ. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 5.7), cerebellum adult (RPKM 5.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dus2 in Genome Data Viewer
Location:
8 D3; 8 53.07 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106738110..106780472)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106011478..106053840)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45752 Neighboring gene dipeptidase 3 Neighboring gene predicted gene, 22972 Neighboring gene dipeptidase 2 Neighboring gene DEAD box helicase 28 Neighboring gene STARR-positive B cell enhancer ABC_E1375 Neighboring gene STARR-positive B cell enhancer ABC_E3801 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108636517-108636718 Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene epithelial splicing regulatory protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nucleo-mitochondrial interactions in Saccharomyces cerevisiae: characterization of a nuclear gene suppressing a defect in mitochondrial tRNA(Asp) processing. Rinaldi T, et al. Gene, 2003 Jan 16. PMID 12559567
  2. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
  3. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FMN binding ISO
Inferred from Sequence Orthology
more info
  
enables FMN binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA dihydrouridine synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA-dihydrouridine20 synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in antiviral innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA dihydrouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA dihydrouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA dihydrouridine synthesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
NP_001288105.1
NP_079794.1
XP_006531341.1
XP_030099573.1
XP_030099575.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301176.1 → NP_001288105.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2

    See identical proteins and their annotated locations for NP_001288105.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses a downstream translation start codon compared to isoform 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK009391, AK077451, BB596733
    UniProtKB/Swiss-Prot
    Q9D7B1
    Conserved Domains (2) summary
    cd02801
    Location:1 → 139
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cd19871
    Location:256 → 323
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

  2. NM_025518.4 → NP_079794.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

    See identical proteins and their annotated locations for NP_079794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK009391, AK077451, BB596733
    Consensus CDS
    CCDS22627.1
    UniProtKB/Swiss-Prot
    Q6PDX2, Q9D7B1
    UniProtKB/TrEMBL
    Q14A90
    Related
    ENSMUSP00000034375.5, ENSMUST00000034375.11
    Conserved Domains (2) summary
    cd02801
    Location:13 → 252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cd19871
    Location:369 → 436
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106738110..106780472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243713.1 → XP_030099573.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X2

    Conserved Domains (2) summary
    cd02801
    Location:75 → 223
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cd19871
    Location:340 → 407
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

  2. XM_030243715.1 → XP_030099575.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3

    Conserved Domains (2) summary
    cd02801
    Location:1 → 139
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cd19871
    Location:256 → 323
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

  3. XM_006531278.3 → XP_006531341.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

    See identical proteins and their annotated locations for XP_006531341.1

    UniProtKB/Swiss-Prot
    Q6PDX2, Q9D7B1
    UniProtKB/TrEMBL
    Q14A90
    Conserved Domains (2) summary
    cd02801
    Location:13 → 252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cd19871
    Location:369 → 436
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7B1.1 GenPept UniProtKB/Swiss-Prot:Q9D7B1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous