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SNRPG small nuclear ribonucleoprotein polypeptide G [ Homo sapiens (human) ]

Gene ID: 6637, updated on 4-Jan-2025

Summary

Official Symbol
SNRPGprovided by HGNC
Official Full Name
small nuclear ribonucleoprotein polypeptide Gprovided by HGNC
Primary source
HGNC:HGNC:11163
See related
Ensembl:ENSG00000143977 MIM:603542; AllianceGenome:HGNC:11163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMG; Sm-G
Summary
The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in colon (RPKM 14.7), appendix (RPKM 13.1) and 25 other tissues See more
Orthologs
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Genomic context

See SNRPG in Genome Data Viewer
Location:
2p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (70281362..70293740, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (70293098..70305490, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70508494..70520872, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11610 Neighboring gene ribosomal protein L39 pseudogene 15 Neighboring gene prenylcysteine oxidase 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70519630-70520537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16007 Neighboring gene uncharacterized LOC124906023 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70527535-70528484 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70528485-70529433 Neighboring gene family with sequence similarity 136 member A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11612 Neighboring gene Sharpr-MPRA regulatory region 10868 Neighboring gene bromodomain containing 7 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein polypeptide G (SNRPG), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SNRPG is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC117317

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding PubMed 
contributes_to RNA binding  
enables U1 snRNP binding  
enables protein binding PubMed 
Items 1 - 20 of 38
Component Evidence Code Pubs
is_active_in P granule  
part_of SMN-Sm protein complex  
part_of SMN-Sm protein complex PubMed 
part_of U1 snRNP  
part_of U1 snRNP PubMed 
part_of U1 snRNP PubMed 
part_of U1 snRNP PubMed 
part_of U12-type spliceosomal complex  
part_of U12-type spliceosomal complex PubMed 
part_of U2 snRNP  
part_of U2 snRNP PubMed 
part_of U2-type catalytic step 2 spliceosome PubMed 
part_of U2-type precatalytic spliceosome PubMed 
part_of U2-type prespliceosome  
part_of U2-type spliceosomal complex PubMed 
part_of U4 snRNP  
part_of U4 snRNP PubMed 
part_of U4 snRNP PubMed 
part_of U4/U6 x U5 tri-snRNP complex PubMed 
part_of U4/U6 x U5 tri-snRNP complex PubMed 
part_of U5 snRNP  
part_of U5 snRNP PubMed 
part_of U7 snRNP PubMed 
part_of catalytic step 2 spliceosome  
part_of catalytic step 2 spliceosome PubMed 
located_in cytosol PubMed 
located_in cytosol  
part_of methylosome PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in nucleus PubMed 
part_of precatalytic spliceosome  
part_of small nuclear ribonucleoprotein complex PubMed 
part_of spliceosomal complex PubMed 
part_of spliceosomal complex PubMed 
part_of spliceosomal complex PubMed 
part_of spliceosomal tri-snRNP complex  
Items 1 - 20 of 38

General protein information

Preferred Names
small nuclear ribonucleoprotein G
Names
sm protein G
snRNP-G
NP_001304094.1
NP_001304095.1
NP_001304096.1
NP_001304097.1
NP_001304098.1
NP_001304100.1
NP_003087.1
XP_016860263.1
XP_054199495.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317165.2NP_001304094.1  small nuclear ribonucleoprotein G isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI742299, BP424287, DW428820
    Consensus CDS
    CCDS82463.1
    UniProtKB/TrEMBL
    C9JVQ0
    Related
    ENSP00000393388.1, ENST00000454893.1
    Conserved Domains (1) summary
    cd01719
    Location:560
    Sm_G; Sm protein G
  2. NM_001317166.2NP_001304095.1  small nuclear ribonucleoprotein G isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AI742299, AV682126, BU540400
    UniProtKB/Swiss-Prot
    A8MWD9
    Conserved Domains (1) summary
    cd01719
    Location:573
    Sm_G; Sm protein G
  3. NM_001317167.1NP_001304096.1  small nuclear ribonucleoprotein G isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AI290354, AI742299
    Consensus CDS
    CCDS82462.1
    UniProtKB/Swiss-Prot
    A8MWD9
    UniProtKB/TrEMBL
    F5H013
    Related
    ENSP00000416334.2, ENST00000413456.6
    Conserved Domains (1) summary
    cd01719
    Location:466
    Sm_G; Sm protein G
  4. NM_001317168.1NP_001304097.1  small nuclear ribonucleoprotein G isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
    Source sequence(s)
    AI742299, BC035103, HY168189
    Consensus CDS
    CCDS82461.1
    UniProtKB/Swiss-Prot
    A8MWD9
    UniProtKB/TrEMBL
    C9J303, Q49AN9
    Related
    ENSP00000441332.1, ENST00000482975.6
    Conserved Domains (1) summary
    cd01719
    Location:162
    Sm_G; Sm protein G
  5. NM_001317169.2NP_001304098.1  small nuclear ribonucleoprotein G isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains two alternate exons in place of the first exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
    Source sequence(s)
    AC079338, AI742299, HY168189
    Consensus CDS
    CCDS82461.1
    UniProtKB/Swiss-Prot
    A8MWD9
    UniProtKB/TrEMBL
    C9J303, Q49AN9
    Related
    ENSP00000402194.1, ENST00000438261.5
    Conserved Domains (1) summary
    cd01719
    Location:162
    Sm_G; Sm protein G
  6. NM_001317171.2NP_001304100.1  small nuclear ribonucleoprotein G isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (f) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AI742299, AV682126, CD109295
    Related
    ENST00000429728.1
    Conserved Domains (1) summary
    cd01719
    Location:256
    Sm_G; Sm protein G
  7. NM_003096.4NP_003087.1  small nuclear ribonucleoprotein G isoform a

    See identical proteins and their annotated locations for NP_003087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the highly conserved isoform (a).
    Source sequence(s)
    AI742299, BC106055, DW428820
    Consensus CDS
    CCDS1903.1
    UniProtKB/Swiss-Prot
    A8MWD9, D6W5G6, P62308, Q15357, Q6IB86
    Related
    ENSP00000272348.2, ENST00000272348.7
    Conserved Domains (1) summary
    cd01719
    Location:574
    Sm_G; Sm protein G

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    70281362..70293740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004774.2XP_016860263.1  small nuclear ribonucleoprotein G isoform X1

    UniProtKB/TrEMBL
    C9JVQ0
    Conserved Domains (1) summary
    cd01719
    Location:560
    Sm_G; Sm protein G

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    70293098..70305490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343520.1XP_054199495.1  small nuclear ribonucleoprotein G isoform X1

    UniProtKB/TrEMBL
    C9JVQ0
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