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Dhrs7 dehydrogenase/reductase 7 [ Mus musculus (house mouse) ]

Gene ID: 66375, updated on 2-Nov-2024

Summary

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Official Symbol
Dhrs7provided by MGI
Official Full Name
dehydrogenase/reductase 7provided by MGI
Primary source
MGI:MGI:1913625
See related
Ensembl:ENSMUSG00000021094 AllianceGenome:MGI:1913625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Retdsr4; Retsdr4; 2310016E22Rik; 5730564L20Rik
Summary
Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity and carbonyl reductase (NADPH) activity. Predicted to be involved in retinol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in diencephalon; heart and pericardium; and lower jaw alveolar sulcus. Orthologous to human DHRS7 (dehydrogenase/reductase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 43.7), mammary gland adult (RPKM 34.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Dhrs7 in Genome Data Viewer
Location:
12 C3; 12 30.23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (72697127..72711678, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (72650353..72664828, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 4 Neighboring gene STARR-seq mESC enhancer starr_32441 Neighboring gene lymphocyte antigen 6 family member E, pseudogene 1 Neighboring gene dehydrogenase/reductase 7 like 1 Neighboring gene STARR-seq mESC enhancer starr_32442 Neighboring gene STARR-seq mESC enhancer starr_32443 Neighboring gene STARR-seq mESC enhancer starr_32444 Neighboring gene STARR-seq mESC enhancer starr_32445 Neighboring gene STARR-seq mESC enhancer starr_32447 Neighboring gene STARR-seq mESC enhancer starr_32449 Neighboring gene STARR-seq mESC enhancer starr_32450 Neighboring gene protein phosphatase 1A, magnesium dependent, alpha isoform Neighboring gene predicted gene, 33785

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. Rattner A, et al. Elife, 2020 Oct 21. PMID 33084572, Free PMC Article
  2. Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4. Velecela V, et al. Development, 2019 Oct 17. PMID 31624071
  3. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. Dai FF, et al. J Biol Chem, 2015 Oct 9. PMID 26272612, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carbonyl reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables carbonyl reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 7
Names
dehydrogenase/reductase (SDR family) member 7
retinal short-chain dehydrogenase/reductase 4
short chain dehydrogenase/reductase family 34C member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025522.5 → NP_079798.2  dehydrogenase/reductase SDR family member 7 precursor

    See identical proteins and their annotated locations for NP_079798.2

    Status: VALIDATED

    Source sequence(s)
    AK014100, CF586466, CX223953
    Consensus CDS
    CCDS49086.1
    UniProtKB/Swiss-Prot
    Q9CXR1
    UniProtKB/TrEMBL
    A0A1Y7VN19
    Related
    ENSMUSP00000021512.10, ENSMUST00000021512.11
    Conserved Domains (1) summary
    cd05332
    Location:48 → 308
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    72697127..72711678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157560.1 → XP_036013453.1  dehydrogenase/reductase SDR family member 7 isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VN19
    Conserved Domains (1) summary
    cd05332
    Location:29 → 289
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXR1.2 GenPept UniProtKB/Swiss-Prot:Q9CXR1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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