Nudt8 nudix hydrolase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt8provided by MGI
Official Full Name: nudix hydrolase 8provided by MGI
Primary source: MGI:MGI:1913637
See related: Ensembl:ENSMUSG00000110949 AllianceGenome:MGI:1913637
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310039H17Rik
Summary: Enables coenzyme A diphosphatase activity; magnesium ion binding activity; and manganese ion binding activity. Involved in nucleoside phosphate catabolic process. Located in mitochondrion. Orthologous to human NUDT8 (nudix hydrolase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 22.0), heart adult (RPKM 21.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19; 19 A

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4050580..4052102)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4000580..4002102)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nudt8 is a novel CoA-degrading enzyme that resides in the mitochondria. Nudt8 specifically hydrolyzes CoA species and has a distinctive preference for manganese ions.
Title: Nudt8 is a novel CoA diphosphohydrolase that resides in the mitochondria.

Submit: New GeneRIF Correction

General gene information

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Readthrough Gm49405

Readthrough gene: Gm49405, Included gene: Doc2g

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coenzyme A diphosphatase activity	EXP Inferred from Experiment more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in biological_process	ND No biological Data available more info
involved_in butyryl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in coenzyme A catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malonyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in medium-chain fatty-acyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in propionyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in succinyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	TAS Traceable Author Statement more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitochondrial coenzyme A diphosphatase NUDT8

Names: nucleoside diphosphate-linked moiety X motif 8, mitochondrial; nudix (nucleoside diphosphate linked moiety X)-type motif 8; nudix motif 8; nudix-type motif 8

NP_079805.1

EC 3.6.1.77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025529.3 → NP_079805.1 mitochondrial coenzyme A diphosphatase NUDT8

See identical proteins and their annotated locations for NP_079805.1

Status: PROVISIONAL

Source sequence(s)

AK045197

Consensus CDS

CCDS29408.1

UniProtKB/Swiss-Prot

Q3TDQ2, Q9CR24

Related

ENSMUSP00000025802.4, ENSMUST00000025802.10

Conserved Domains (1) summary

cd03426
Location:31 → 186

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...