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Exosc7 exosome component 7 [ Mus musculus (house mouse) ]

Gene ID: 66446, updated on 2-Nov-2024

Summary

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Official Symbol
Exosc7provided by MGI
Official Full Name
exosome component 7provided by MGI
Primary source
MGI:MGI:1913696
See related
Ensembl:ENSMUSG00000025785 AllianceGenome:MGI:1913696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0116; 2610002K22Rik
Summary
Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytosol and nucleolus. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in several structures, including brain; genitourinary system; gut; submandibular gland primordium; and tooth. Orthologous to human EXOSC7 (exosome component 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 25.3), CNS E11.5 (RPKM 23.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Exosc7 in Genome Data Viewer
Location:
9 F4; 9 73.8 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122942310..122965194)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123113231..123136129)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9856 Neighboring gene transmembrane protein 42 Neighboring gene transglutaminase 4 (prostate) Neighboring gene zinc finger, DHHC domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_25557 Neighboring gene C-type lectin domain family 3, member b Neighboring gene predicted gene, 23323

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The yin and yang of the exosome. Butler JS. Trends Cell Biol, 2002 Feb. PMID 11849973
  2. Exosome complex components 1 and 2 are vital for early mammalian development. Srinivasan S, et al. Gene Expr Patterns, 2024 Mar. PMID 37940010,
  3. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Chen CY, et al. Cell, 2001 Nov 16. PMID 11719186
  4. Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Ulmke PA, et al. Development, 2021 Feb 8. PMID 33462115, Free PMC Article
  5. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in TRAMP-dependent tRNA surveillance pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U1 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U5 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nucleolar exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exosome complex exonuclease RRP42
Names
ribosomal RNA-processing protein 42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081188.2 → NP_001074657.1  exosome complex exonuclease RRP42 isoform 1

    See identical proteins and their annotated locations for NP_001074657.1

    Status: VALIDATED

    Source sequence(s)
    AC134248
    Consensus CDS
    CCDS40815.1
    UniProtKB/Swiss-Prot
    Q4VBW5, Q9CT77, Q9D0M0
    UniProtKB/TrEMBL
    Q7TMX6
    Related
    ENSMUSP00000026891.5, ENSMUST00000026891.5
    Conserved Domains (1) summary
    cd11367
    Location:5 → 276
    RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome

  2. NM_001418861.1 → NP_001405790.1  exosome complex exonuclease RRP42 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134248

  3. NM_001418862.1 → NP_001405791.1  exosome complex exonuclease RRP42 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134248

  4. NM_001418863.1 → NP_001405792.1  exosome complex exonuclease RRP42 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134248

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    122942310..122965194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512207.5 → XP_006512270.1  exosome complex exonuclease RRP42 isoform X1

    See identical proteins and their annotated locations for XP_006512270.1

    Conserved Domains (1) summary
    cd11367
    Location:8 → 198
    RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025568.1: Suppressed sequence

    Description
    NM_025568.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0M0.2 GenPept UniProtKB/Swiss-Prot:Q9D0M0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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