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Slx Sycp3 like X-linked [ Mus musculus (house mouse) ]

Gene ID: 664829, updated on 2-Nov-2024

Summary

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Official Symbol
Slxprovided by MGI
Official Full Name
Sycp3 like X-linkedprovided by MGI
Primary source
MGI:MGI:99543
See related
Ensembl:ENSMUSG00000095063 AllianceGenome:MGI:99543
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xmr; EG664958
Summary
Acts upstream of or within several processes, including sex determination; single fertilization; and spermatid differentiation. Located in XY body; cytoplasm; and nucleus. Is expressed in ovary; primary spermatocyte; spermatid; and testis. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 10.1) See more
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Genomic context

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See Slx in Genome Data Viewer
Location:
X A2; X 18.15 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (26477957..26500865, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (26522657..26545565, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46944 Neighboring gene predicted gene 2036 Neighboring gene predicted pseudogene 2005 Neighboring gene RIKEN cDNA 1700040G22 gene Neighboring gene predicted gene 14525

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Neofunctionalized X-Linked Ampliconic Gene Family Is Essential for Male Fertility and Equal Sex Ratio in Mice. Kruger AN, et al. Curr Biol, 2019 Nov 4. PMID 31630956, Free PMC Article
  2. Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation. Cocquet J, et al. Mol Biol Cell, 2010 Oct 15. PMID 20739462, Free PMC Article
  3. Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents. Moretti C, et al. Mol Biol Evol, 2020 Dec 16. PMID 32658962, Free PMC Article
  4. Sex-specific gene expression during meiotic prophase I: Xlr (X linked, lymphocyte regulated), not its male homologue Xmr (Xlr related, meiosis regulated), is expressed in mouse oocytes. Escalier D, et al. Biol Reprod, 2002 Nov. PMID 12390899
  5. A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. Cocquet J, et al. PLoS Genet, 2012 Sep. PMID 23028340, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents.
    Title: Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents.
  2. almost exclusively expressed in spermatids; findings show the gene previously known as Xmr is now officially know as Slx, Sycp3-like, X-linked
    Title: Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sex determination IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within single fertilization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in XY body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sycp3 like X-linked

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136476.1 → NP_001129948.1  Sycp3 like X-linked

    Status: PROVISIONAL

    Source sequence(s)
    BX322592, CF981602
    Consensus CDS
    CCDS53026.1
    UniProtKB/TrEMBL
    D3Z347
    Related
    ENSMUSP00000094676.4, ENSMUST00000096913.4
    Conserved Domains (1) summary
    pfam04803
    Location:130 → 209
    Cor1; Cor1/Xlr/Xmr conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    26477957..26500865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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