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Ntpcr nucleoside-triphosphatase, cancer-related [ Mus musculus (house mouse) ]

Gene ID: 66566, updated on 28-Oct-2024

Summary

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Official Symbol
Ntpcrprovided by MGI
Official Full Name
nucleoside-triphosphatase, cancer-relatedprovided by MGI
Primary source
MGI:MGI:1913816
See related
Ensembl:ENSMUSG00000031851 AllianceGenome:MGI:1913816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310079N02Rik
Summary
Predicted to enable ribonucleoside triphosphate phosphatase activity. Orthologous to human NTPCR (nucleoside-triphosphatase, cancer-related). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 15.1), bladder adult (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ntpcr in Genome Data Viewer
Location:
8 E2; 8 73.65 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (126456724..126474974)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (125729975..125748235)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39282 Neighboring gene STARR-seq mESC enhancer starr_23044 Neighboring gene STARR-seq mESC enhancer starr_23045 Neighboring gene predicted gene, 39283 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:128265368-128265564 Neighboring gene predicted gene, 39285 Neighboring gene pecanex homolog 2 Neighboring gene predicted gene, 39284

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables CTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoside triphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
cancer-related nucleoside-triphosphatase homolog
Names
NTPase
nucleoside triphosphate phosphohydrolase
nucleoside-triphosphatase C1orf57 homolog
NP_001297617.1
NP_079912.1
XP_006531346.2
XP_006531348.1
XP_006531349.1
XP_006531350.1
XP_030099583.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310688.1 → NP_001297617.1  cancer-related nucleoside-triphosphatase homolog isoform 2

    See identical proteins and their annotated locations for NP_001297617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 3' coding region and uses a different 3' terminal exon compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC151909, AK010823, AK086714, BY515428
    Consensus CDS
    CCDS80944.1
    UniProtKB/TrEMBL
    Q8C373
    Related
    ENSMUSP00000069384.6, ENSMUST00000065135.12
    Conserved Domains (2) summary
    smart00382
    Location:3 → 59
    AAA; ATPases associated with a variety of cellular activities
    cl21455
    Location:4 → 106
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_025636.5 → NP_079912.1  cancer-related nucleoside-triphosphatase homolog isoform 1

    See identical proteins and their annotated locations for NP_079912.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC151909, AK006433, AK010823
    Consensus CDS
    CCDS22781.1
    UniProtKB/Swiss-Prot
    Q9CQA9
    UniProtKB/TrEMBL
    Q9CX79
    Related
    ENSMUSP00000034313.7, ENSMUST00000034313.13
    Conserved Domains (2) summary
    smart00382
    Location:3 → 59
    AAA; ATPases associated with a variety of cellular activities
    pfam03266
    Location:4 → 182
    NTPase_1; NTPase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    126456724..126474974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531285.4 → XP_006531348.1  cancer-related nucleoside-triphosphatase homolog isoform X2

    See identical proteins and their annotated locations for XP_006531348.1

    Conserved Domains (1) summary
    cl38985
    Location:20 → 130
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_030243723.1 → XP_030099583.1  cancer-related nucleoside-triphosphatase homolog isoform X2

    Conserved Domains (1) summary
    cl38985
    Location:20 → 130
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_006531283.4 → XP_006531346.2  cancer-related nucleoside-triphosphatase homolog isoform X1

    UniProtKB/TrEMBL
    Q9CX79
    Conserved Domains (1) summary
    pfam03266
    Location:4 → 148
    NTPase_1

  4. XM_006531286.5 → XP_006531349.1  cancer-related nucleoside-triphosphatase homolog isoform X2

    See identical proteins and their annotated locations for XP_006531349.1

    Conserved Domains (1) summary
    cl38985
    Location:20 → 130
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_006531287.4 → XP_006531350.1  cancer-related nucleoside-triphosphatase homolog isoform X2

    See identical proteins and their annotated locations for XP_006531350.1

    Conserved Domains (1) summary
    cl38985
    Location:20 → 130
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQA9.1 GenPept UniProtKB/Swiss-Prot:Q9CQA9

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