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Atg4a autophagy related 4A, cysteine peptidase [ Mus musculus (house mouse) ]

Gene ID: 666468, updated on 2-Nov-2024

Summary

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Official Symbol
Atg4aprovided by MGI
Official Full Name
autophagy related 4A, cysteine peptidaseprovided by MGI
Primary source
MGI:MGI:2147903
See related
Ensembl:ENSMUSG00000079418 AllianceGenome:MGI:2147903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apg4a; Autl2; Atg4al
Summary
Predicted to enable cysteine-type endopeptidase activity and protein-phosphatidylethanolamide deconjugating activity. Predicted to be involved in macroautophagy; protein delipidation; and protein processing. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human ATG4A (autophagy related 4A cysteine peptidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in genital fat pad adult (RPKM 11.0), placenta adult (RPKM 5.0) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Atg4a in Genome Data Viewer
Location:
X F1; X 61.67 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (139854594..139947190)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140953845..141164194)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48010 Neighboring gene STARR-positive B cell enhancer ABC_E3263 Neighboring gene V-set and immunoglobulin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_48011 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Neighboring gene STARR-positive B cell enhancer mm9_chrX:137591358-137591658 Neighboring gene collagen, type IV, alpha 6 Neighboring gene predicted gene, 39539 Neighboring gene prohibitin pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Unraveling the roles of Atg4 proteases from autophagy modulation to targeted cancer therapy. Zhang L, et al. Cancer Lett, 2016 Apr 1. PMID 26805760
  2. The functional and pathologic relevance of autophagy proteases. Fernández ÁF, et al. J Clin Invest, 2015 Jan. PMID 25654548, Free PMC Article
  3. [miR-144 regulates BCG- and rapamycin-induced autophagy by targeting Atg4a in RAW264.7 cells]. Zhou L, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2015 Feb. PMID 25652854
  4. Measurement of the Activity of the Atg4 Cysteine Proteases. Li M, et al. Methods Enzymol, 2017. PMID 28253956, Free PMC Article
  5. Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival. Li H, et al. Cell Rep, 2022 Oct 4. PMID 36198274

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-144 inhibits the autophagy-related gene Atg4a expression in Mycobacterium tuberculosis infection.
    Title: [miR-144 regulates BCG- and rapamycin-induced autophagy by targeting Atg4a in RAW264.7 cells].
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC107179

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-phosphatidylethanolamide deconjugating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-phosphatidylethanolamide deconjugating activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-phosphatidylethanolamide deconjugating activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in aggrephagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein delipidation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein delipidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cysteine protease ATG4A
Names
APG4 (ATG4) autophagy-related homolog A
AUT-like 2, cysteine endopeptidase
autophagin 2
autophagy 4 homolog A
autophagy-related 4A
autophagy-related cysteine endopeptidase 2
autophagy-related protein 4 homolog A
cysteine protease APG4A
NP_001366610.1
NP_001366611.1
NP_001366612.1
NP_001366613.1
NP_777364.3
XP_017174089.1
XP_017174090.1
XP_017174091.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379681.1 → NP_001366610.1  cysteine protease ATG4A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672306, AL691493, CR478060, CT025930
    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:109 → 399
    Peptidase_C54; Peptidase family C54

  2. NM_001379682.1 → NP_001366611.1  cysteine protease ATG4A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672306, AL691493, CR478060, CT025930
    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:42 → 331
    Peptidase_C54; Peptidase family C54

  3. NM_001379683.1 → NP_001366612.1  cysteine protease ATG4A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672306, AL691493, CR478060, CT025930
    UniProtKB/TrEMBL
    A0A0G2JFS9, A0A7N9VS64
    Related
    ENSMUSP00000159430.2, ENSMUST00000239541.1
    Conserved Domains (1) summary
    pfam03416
    Location:41 → 308
    Peptidase_C54; Peptidase family C54

  4. NM_001379684.1 → NP_001366613.1  cysteine protease ATG4A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672306, AL691493, CR478060, CT025930
    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:1 → 255
    Peptidase_C54; Peptidase family C54

  5. NM_174875.5 → NP_777364.3  cysteine protease ATG4A isoform 1

    See identical proteins and their annotated locations for NP_777364.3

    Status: VALIDATED

    Source sequence(s)
    AK041379, BB638045, BY287162, CJ057919, CO425906
    Consensus CDS
    CCDS85810.1
    UniProtKB/Swiss-Prot
    Q811B8, Q8C9S8
    UniProtKB/TrEMBL
    A0A0G2JFS9, Q5EBK1
    Related
    ENSMUSP00000108595.2, ENSMUST00000112971.2
    Conserved Domains (1) summary
    pfam03416
    Location:43 → 332
    Peptidase_C54; Peptidase family C54

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    139854594..139947190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318600.2 → XP_017174089.1  cysteine protease ATG4A isoform X1

    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:108 → 375
    Peptidase_C54; Peptidase family C54

  2. XM_017318602.3 → XP_017174091.1  cysteine protease ATG4A isoform X2

    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:38 → 328
    Peptidase_C54; Peptidase family C54

  3. XM_017318601.3 → XP_017174090.1  cysteine protease ATG4A isoform X2

    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:38 → 328
    Peptidase_C54; Peptidase family C54

RNA

  1. XR_004940359.1 RNA Sequence

    Related
    ENSMUST00000239544.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C9S8.2 GenPept UniProtKB/Swiss-Prot:Q8C9S8

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