U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmem249 transmembrane protein 249 [ Mus musculus (house mouse) ]

Gene ID: 666504, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Tmem249provided by MGI
Official Full Name
transmembrane protein 249provided by MGI
Primary source
MGI:MGI:3647471
See related
Ensembl:ENSMUSG00000116376 AllianceGenome:MGI:3647471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm8140; Catsperq; EG666504
Summary
Located in sperm principal piece. Part of CatSper complex. Orthologous to human TMEM249 (transmembrane protein 249). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 85.3) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tmem249 in Genome Data Viewer
Location:
15 D3; 15 36.03 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76417411..76419197, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76533211..76534997, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene scratch family zinc finger 1 Neighboring gene predicted gene, 46533 Neighboring gene STARR-positive B cell enhancer ABC_E3144 Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene solute carrier protein 52, member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking. Huang X, et al. Proc Natl Acad Sci U S A, 2023 Sep 26. PMID 37725640, Free PMC Article
  2. A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking. Huang X, et al. bioRxiv, 2023 Mar 17. PMID 36993167, Free PMC Article
  3. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of CatSper complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cation channel sperm-associated auxiliary subunit TMEM249
Names
Catsper theta

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378247.1 → NP_001365176.1  cation channel sperm-associated auxiliary subunit TMEM249

    Status: VALIDATED

    Source sequence(s)
    AC157566
    UniProtKB/Swiss-Prot
    A0A2R8VHF7
    Related
    ENSMUSP00000155040.2, ENSMUST00000230604.2
    Conserved Domains (1) summary
    pfam15158
    Location:1 → 144
    DUF4579; Domain of unknown function (DUF4579)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76417411..76419197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159542.1 → XP_036015435.1  cation channel sperm-associated auxiliary subunit TMEM249 isoform X1

    UniProtKB/TrEMBL
    A0AAQ4VMS7
    Conserved Domains (1) summary
    pfam15158
    Location:7 → 167
    DUF4579; Domain of unknown function (DUF4579)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A2R8VHF7.1 GenPept UniProtKB/Swiss-Prot:A0A2R8VHF7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials