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Srp72 signal recognition particle 72 [ Mus musculus (house mouse) ]

Gene ID: 66661, updated on 2-Nov-2024

Summary

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Official Symbol
Srp72provided by MGI
Official Full Name
signal recognition particle 72provided by MGI
Primary source
MGI:MGI:1333795
See related
Ensembl:ENSMUSG00000036323 AllianceGenome:MGI:1333795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
72kDa; 5730576P14Rik
Summary
Predicted to enable 7S RNA binding activity; TPR domain binding activity; and signal recognition particle binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in endoplasmic reticulum and nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP72 (signal recognition particle 72). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 28.9), limb E14.5 (RPKM 23.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Srp72 in Genome Data Viewer
Location:
5 C3.3; 5 41.45 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (77122548..77147782)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76974701..76999935)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase Neighboring gene predicted gene, 54291 Neighboring gene RIKEN cDNA 1700112J05 gene Neighboring gene ADP-ribosylation factor-like 9 Neighboring gene sperm microtubule associated protein 2 like Neighboring gene microRNA 12199

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The 72-kDa component of signal recognition particle is cleaved during apoptosis. Utz PJ, et al. J Biol Chem, 1998 Dec 25. PMID 9857079
  2. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621
  3. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
  4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 7S RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables TPR domain binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables signal recognition particle binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of signal recognition particle ISO
Inferred from Sequence Orthology
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting ISA
Inferred from Sequence Alignment
more info
 PubMed 
part_of signal recognition particle, endoplasmic reticulum targeting ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal recognition particle subunit SRP72
Names
signal recognition particle 72 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025691.1 → NP_079967.1  signal recognition particle subunit SRP72

    See identical proteins and their annotated locations for NP_079967.1

    Status: VALIDATED

    Source sequence(s)
    AK017869, AK133784, BE635216, BY393170, BY647692
    Consensus CDS
    CCDS39119.1
    UniProtKB/TrEMBL
    E9Q740, F8VQC1
    Related
    ENSMUSP00000098648.4, ENSMUST00000101087.10
    Conserved Domains (5) summary
    sd00006
    Location:176 → 204
    TPR; TPR repeat [structural motif]
    sd00004
    Location:341 → 367
    PPR; PPR repeat [structural motif]
    pfam08492
    Location:531 → 584
    SRP72; SRP72 RNA-binding domain
    pfam17004
    Location:36 → 157
    SRP_TPR_like; Putative TPR-like repeat
    cl26002
    Location:24 → 503
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    77122548..77147782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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