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Klhl28 kelch-like 28 [ Mus musculus (house mouse) ]

Gene ID: 66689, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl28provided by MGI
Official Full Name
kelch-like 28provided by MGI
Primary source
MGI:MGI:1913939
See related
Ensembl:ENSMUSG00000020948 AllianceGenome:MGI:1913939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Btbd5; 2810440N09Rik; 4122402F11Rik; 4931401E10Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in ganglia and sensory organ. Orthologous to human KLHL28 (kelch like family member 28). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 2.1), CNS E18 (RPKM 2.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Klhl28 in Genome Data Viewer
Location:
12 C1; 12 27.21 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (64985603..65012365, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (64941486..64965581, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_32310 Neighboring gene STARR-positive B cell enhancer mm9_chr12:66018613-66018914 Neighboring gene predicted gene, 51965 Neighboring gene predicted gene 527 Neighboring gene TOG array regulator of axonemal microtubules 1 Neighboring gene STARR-seq mESC enhancer starr_32311 Neighboring gene STARR-positive B cell enhancer ABC_E7138 Neighboring gene predicted gene, 51966 Neighboring gene STARR-seq mESC enhancer starr_32313 Neighboring gene pre-mRNA processing factor 39 Neighboring gene predicted gene, 25970

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47075

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 28
Names
BTB (POZ) domain containing 5
BTB/POZ domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025707.3 → NP_079983.1  kelch-like protein 28

    See identical proteins and their annotated locations for NP_079983.1

    Status: PROVISIONAL

    Source sequence(s)
    AC159632
    Consensus CDS
    CCDS25938.1
    UniProtKB/Swiss-Prot
    Q9CR40, Q9CYV0
    Related
    ENSMUSP00000152602.2, ENSMUST00000222508.2
    Conserved Domains (2) summary
    PHA03098
    Location:35 → 553
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423 → 465
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    64985603..65012365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516156.5 → XP_006516219.1  kelch-like protein 28 isoform X1

    See identical proteins and their annotated locations for XP_006516219.1

    UniProtKB/Swiss-Prot
    Q9CR40, Q9CYV0
    Related
    ENSMUSP00000021331.8, ENSMUST00000021331.9
    Conserved Domains (2) summary
    PHA03098
    Location:35 → 553
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423 → 465
    Kelch; KELCH repeat [structural motif]

  2. XM_006516157.5 → XP_006516220.1  kelch-like protein 28 isoform X2

    Conserved Domains (3) summary
    PHA03098
    Location:35 → 522
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:376 → 419
    Kelch; KELCH repeat [structural motif]
    cd18257
    Location:17 → 134
    BTB_POZ_KLHL28_BTBD5; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR40.1 GenPept UniProtKB/Swiss-Prot:Q9CR40

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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